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Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751898/ https://www.ncbi.nlm.nih.gov/pubmed/26917957 http://dx.doi.org/10.2147/COPD.S90626 |
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author | Mahboub, Bassam Alzaabi, Ashraf Iqbal, Mohammed Nizam Salhi, Hocine Lahlou, Aïcha Tariq, Luqman El Hasnaoui, Abdelkader |
author_facet | Mahboub, Bassam Alzaabi, Ashraf Iqbal, Mohammed Nizam Salhi, Hocine Lahlou, Aïcha Tariq, Luqman El Hasnaoui, Abdelkader |
author_sort | Mahboub, Bassam |
collection | PubMed |
description | OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven countries in the Middle East and North Africa, including Pakistan. The study population consisted of a sample of subjects with COPD for whom the presence of comorbidities was documented. Three questionnaires were used. The screening questionnaire identified subjects who fulfilled an epidemiological case definition of COPD and documented any potential comorbidities; the detailed COPD questionnaire collected data on respiratory symptoms, COPD exacerbations, and comorbidities associated with COPD; the COPD Assessment Test collected data on the impact of respiratory symptoms on well-being and daily life. RESULTS: A total of 2,187 subjects were positively screened for COPD, of whom 1,392 completed the detailed COPD questionnaire. COPD subjects were more likely to report comorbidities (55.2%) than subjects without COPD (39.1%, P<0.0001), most frequently cardiovascular diseases. In subjects who screened positively for COPD, the presence of comorbidities was significantly (P=0.03) associated with a COPD Assessment Test score ≥10 and with antecedents of COPD exacerbations in the previous 6 months (P=0.03). CONCLUSION: Comorbidities are frequent in COPD and associated with more severe respiratory symptoms. This highlights the importance of identification and appropriate management of comorbidities in all subjects with a diagnosis of COPD. |
format | Online Article Text |
id | pubmed-4751898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47518982016-02-25 Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations Mahboub, Bassam Alzaabi, Ashraf Iqbal, Mohammed Nizam Salhi, Hocine Lahlou, Aïcha Tariq, Luqman El Hasnaoui, Abdelkader Int J Chron Obstruct Pulmon Dis Original Research OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven countries in the Middle East and North Africa, including Pakistan. The study population consisted of a sample of subjects with COPD for whom the presence of comorbidities was documented. Three questionnaires were used. The screening questionnaire identified subjects who fulfilled an epidemiological case definition of COPD and documented any potential comorbidities; the detailed COPD questionnaire collected data on respiratory symptoms, COPD exacerbations, and comorbidities associated with COPD; the COPD Assessment Test collected data on the impact of respiratory symptoms on well-being and daily life. RESULTS: A total of 2,187 subjects were positively screened for COPD, of whom 1,392 completed the detailed COPD questionnaire. COPD subjects were more likely to report comorbidities (55.2%) than subjects without COPD (39.1%, P<0.0001), most frequently cardiovascular diseases. In subjects who screened positively for COPD, the presence of comorbidities was significantly (P=0.03) associated with a COPD Assessment Test score ≥10 and with antecedents of COPD exacerbations in the previous 6 months (P=0.03). CONCLUSION: Comorbidities are frequent in COPD and associated with more severe respiratory symptoms. This highlights the importance of identification and appropriate management of comorbidities in all subjects with a diagnosis of COPD. Dove Medical Press 2016-02-05 /pmc/articles/PMC4751898/ /pubmed/26917957 http://dx.doi.org/10.2147/COPD.S90626 Text en © 2016 Mahboub et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Mahboub, Bassam Alzaabi, Ashraf Iqbal, Mohammed Nizam Salhi, Hocine Lahlou, Aïcha Tariq, Luqman El Hasnaoui, Abdelkader Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title | Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title_full | Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title_fullStr | Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title_full_unstemmed | Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title_short | Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations |
title_sort | comorbidities associated with copd in the middle east and north africa region: association with severity and exacerbations |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751898/ https://www.ncbi.nlm.nih.gov/pubmed/26917957 http://dx.doi.org/10.2147/COPD.S90626 |
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