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Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations

OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven c...

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Autores principales: Mahboub, Bassam, Alzaabi, Ashraf, Iqbal, Mohammed Nizam, Salhi, Hocine, Lahlou, Aïcha, Tariq, Luqman, El Hasnaoui, Abdelkader
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751898/
https://www.ncbi.nlm.nih.gov/pubmed/26917957
http://dx.doi.org/10.2147/COPD.S90626
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author Mahboub, Bassam
Alzaabi, Ashraf
Iqbal, Mohammed Nizam
Salhi, Hocine
Lahlou, Aïcha
Tariq, Luqman
El Hasnaoui, Abdelkader
author_facet Mahboub, Bassam
Alzaabi, Ashraf
Iqbal, Mohammed Nizam
Salhi, Hocine
Lahlou, Aïcha
Tariq, Luqman
El Hasnaoui, Abdelkader
author_sort Mahboub, Bassam
collection PubMed
description OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven countries in the Middle East and North Africa, including Pakistan. The study population consisted of a sample of subjects with COPD for whom the presence of comorbidities was documented. Three questionnaires were used. The screening questionnaire identified subjects who fulfilled an epidemiological case definition of COPD and documented any potential comorbidities; the detailed COPD questionnaire collected data on respiratory symptoms, COPD exacerbations, and comorbidities associated with COPD; the COPD Assessment Test collected data on the impact of respiratory symptoms on well-being and daily life. RESULTS: A total of 2,187 subjects were positively screened for COPD, of whom 1,392 completed the detailed COPD questionnaire. COPD subjects were more likely to report comorbidities (55.2%) than subjects without COPD (39.1%, P<0.0001), most frequently cardiovascular diseases. In subjects who screened positively for COPD, the presence of comorbidities was significantly (P=0.03) associated with a COPD Assessment Test score ≥10 and with antecedents of COPD exacerbations in the previous 6 months (P=0.03). CONCLUSION: Comorbidities are frequent in COPD and associated with more severe respiratory symptoms. This highlights the importance of identification and appropriate management of comorbidities in all subjects with a diagnosis of COPD.
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spelling pubmed-47518982016-02-25 Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations Mahboub, Bassam Alzaabi, Ashraf Iqbal, Mohammed Nizam Salhi, Hocine Lahlou, Aïcha Tariq, Luqman El Hasnaoui, Abdelkader Int J Chron Obstruct Pulmon Dis Original Research OBJECTIVE: To assess the frequency of comorbidities in subjects with COPD and their association with respiratory symptom severity and COPD exacerbations. MATERIALS AND METHODS: This was an analysis of the BREATHE study, a cross-sectional survey of COPD conducted in the general population of eleven countries in the Middle East and North Africa, including Pakistan. The study population consisted of a sample of subjects with COPD for whom the presence of comorbidities was documented. Three questionnaires were used. The screening questionnaire identified subjects who fulfilled an epidemiological case definition of COPD and documented any potential comorbidities; the detailed COPD questionnaire collected data on respiratory symptoms, COPD exacerbations, and comorbidities associated with COPD; the COPD Assessment Test collected data on the impact of respiratory symptoms on well-being and daily life. RESULTS: A total of 2,187 subjects were positively screened for COPD, of whom 1,392 completed the detailed COPD questionnaire. COPD subjects were more likely to report comorbidities (55.2%) than subjects without COPD (39.1%, P<0.0001), most frequently cardiovascular diseases. In subjects who screened positively for COPD, the presence of comorbidities was significantly (P=0.03) associated with a COPD Assessment Test score ≥10 and with antecedents of COPD exacerbations in the previous 6 months (P=0.03). CONCLUSION: Comorbidities are frequent in COPD and associated with more severe respiratory symptoms. This highlights the importance of identification and appropriate management of comorbidities in all subjects with a diagnosis of COPD. Dove Medical Press 2016-02-05 /pmc/articles/PMC4751898/ /pubmed/26917957 http://dx.doi.org/10.2147/COPD.S90626 Text en © 2016 Mahboub et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Mahboub, Bassam
Alzaabi, Ashraf
Iqbal, Mohammed Nizam
Salhi, Hocine
Lahlou, Aïcha
Tariq, Luqman
El Hasnaoui, Abdelkader
Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title_full Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title_fullStr Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title_full_unstemmed Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title_short Comorbidities associated with COPD in the Middle East and North Africa region: association with severity and exacerbations
title_sort comorbidities associated with copd in the middle east and north africa region: association with severity and exacerbations
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751898/
https://www.ncbi.nlm.nih.gov/pubmed/26917957
http://dx.doi.org/10.2147/COPD.S90626
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