EZH2 inhibition re-sensitizes multidrug resistant B-cell lymphomas to etoposide mediated apoptosis

Reactivation of apoptotic pathways is an attractive strategy for patients with treatment-resistant B-cell lymphoma. The tumor suppressor, p53 is central for apoptotic response to multiple DNA damaging agents used to treat aggressive B-cell lymphomas, including etoposide. It has been demonstrated tha...

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Detalles Bibliográficos
Autores principales: Smonskey, Matthew, Lasorsa, Elena, Rosario, Spencer, Kirk, Jason S., Hernandez-Ilizaliturri, Francisco J., Ellis, Leigh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751913/
https://www.ncbi.nlm.nih.gov/pubmed/26973857

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