Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258

A “high risk” clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well...

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Autores principales: Dhar, Sorabh, Martin, Emily T., Lephart, Paul R., McRoberts, John P., Chopra, Teena, Burger, Timothy T., Tal-Jasper, Ruthy, Hayakawa, Kayoko, Ofer-Friedman, Hadas, Lazarovitch, Tsilia, Zaidenstein, Ronit, Perez, Federico, Bonomo, Robert A., Kaye, Keith S., Marchaim, Dror
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751918/
https://www.ncbi.nlm.nih.gov/pubmed/26885543
http://dx.doi.org/10.1093/ofid/ofv213
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author Dhar, Sorabh
Martin, Emily T.
Lephart, Paul R.
McRoberts, John P.
Chopra, Teena
Burger, Timothy T.
Tal-Jasper, Ruthy
Hayakawa, Kayoko
Ofer-Friedman, Hadas
Lazarovitch, Tsilia
Zaidenstein, Ronit
Perez, Federico
Bonomo, Robert A.
Kaye, Keith S.
Marchaim, Dror
author_facet Dhar, Sorabh
Martin, Emily T.
Lephart, Paul R.
McRoberts, John P.
Chopra, Teena
Burger, Timothy T.
Tal-Jasper, Ruthy
Hayakawa, Kayoko
Ofer-Friedman, Hadas
Lazarovitch, Tsilia
Zaidenstein, Ronit
Perez, Federico
Bonomo, Robert A.
Kaye, Keith S.
Marchaim, Dror
author_sort Dhar, Sorabh
collection PubMed
description A “high risk” clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with bla(KPC) production and with resistance to an increased number of antimicrobials. Clinical outcomes were not different. Based on this analysis, one cannot rely solely on the presence of bla(KPC) in order to diagnose CRKP.
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spelling pubmed-47519182016-02-16 Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258 Dhar, Sorabh Martin, Emily T. Lephart, Paul R. McRoberts, John P. Chopra, Teena Burger, Timothy T. Tal-Jasper, Ruthy Hayakawa, Kayoko Ofer-Friedman, Hadas Lazarovitch, Tsilia Zaidenstein, Ronit Perez, Federico Bonomo, Robert A. Kaye, Keith S. Marchaim, Dror Open Forum Infect Dis Brief Reports A “high risk” clone of carbapenem-resistant Klebsiella pneumoniae (CRKP) identified by multilocus sequence typing (MLST) as sequence type (ST) 258 has disseminated worldwide. As the molecular epidemiology of the CRE pandemic continues to evolve, the clinical impact of non-ST258 strains is less well defined. We conducted an epidemiological investigation of CRKP based on strains MLST. Among 68 CRKP patients, 61 were ST258 and 7 belonged to non-ST258. Klebsiella pneumoniae ST258 strains were significantly associated with bla(KPC) production and with resistance to an increased number of antimicrobials. Clinical outcomes were not different. Based on this analysis, one cannot rely solely on the presence of bla(KPC) in order to diagnose CRKP. Oxford University Press 2016-02-12 /pmc/articles/PMC4751918/ /pubmed/26885543 http://dx.doi.org/10.1093/ofid/ofv213 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Dhar, Sorabh
Martin, Emily T.
Lephart, Paul R.
McRoberts, John P.
Chopra, Teena
Burger, Timothy T.
Tal-Jasper, Ruthy
Hayakawa, Kayoko
Ofer-Friedman, Hadas
Lazarovitch, Tsilia
Zaidenstein, Ronit
Perez, Federico
Bonomo, Robert A.
Kaye, Keith S.
Marchaim, Dror
Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title_full Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title_fullStr Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title_full_unstemmed Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title_short Risk Factors and Outcomes for Carbapenem-Resistant Klebsiella pneumoniae Isolation, Stratified by Its Multilocus Sequence Typing: ST258 Versus Non-ST258
title_sort risk factors and outcomes for carbapenem-resistant klebsiella pneumoniae isolation, stratified by its multilocus sequence typing: st258 versus non-st258
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751918/
https://www.ncbi.nlm.nih.gov/pubmed/26885543
http://dx.doi.org/10.1093/ofid/ofv213
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