Cargando…

Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011

Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic in Puerto Rico. Severe dengue usually occurs in individuals previously infected with DENV or among infants born to previously infected mothers. To describe clinical features of dengue in infants, we re...

Descripción completa

Detalles Bibliográficos
Autores principales: Hause, Anne M., Perez-Padilla, Janice, Horiuchi, Kalanthe, Han, George S., Hunsperger, Elizabeth, Aiwazian, Jonathan, Margolis, Harold S., Tomashek, Kay M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751950/
https://www.ncbi.nlm.nih.gov/pubmed/26711519
http://dx.doi.org/10.4269/ajtmh.15-0382
_version_ 1782415656491155456
author Hause, Anne M.
Perez-Padilla, Janice
Horiuchi, Kalanthe
Han, George S.
Hunsperger, Elizabeth
Aiwazian, Jonathan
Margolis, Harold S.
Tomashek, Kay M.
author_facet Hause, Anne M.
Perez-Padilla, Janice
Horiuchi, Kalanthe
Han, George S.
Hunsperger, Elizabeth
Aiwazian, Jonathan
Margolis, Harold S.
Tomashek, Kay M.
author_sort Hause, Anne M.
collection PubMed
description Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic in Puerto Rico. Severe dengue usually occurs in individuals previously infected with DENV or among infants born to previously infected mothers. To describe clinical features of dengue in infants, we retrospectively characterized dengue patients aged < 18 months reported to the Passive Dengue Surveillance System (PDSS) during 1999–2011. To determine frequency of signs, symptoms, and disease severity, case report forms and medical records were evaluated for patients who tested positive for dengue by reverse transcriptase polymerase chain reaction or anti-DENV immunoglobulin Menzyme-linked immunosorbent assay. Of 4,178 reported patients aged < 18 months, 813 (19%) were laboratory positive. Of these, most had fever (92%), rash (53%), bleeding manifestations (52%), and thrombocytopenia (52%). Medical records were available for 145 (31%) of 472 hospitalized patients, of which 40% had dengue, 23% had dengue with warning signs, and 33% had severe dengue. Mean age of patients with severe dengue was 8 months. Anti-DENV immunoglobulin G (IgG) titers were not statistically different in patients with (50%) and without (59%) severe dengue. In this study, one-third of DENV-infected infants met the severe dengue case definition. The role of maternal anti-DENV IgG in development of severe disease warrants further study in prospective cohorts of mother-infant pairs.
format Online
Article
Text
id pubmed-4751950
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The American Society of Tropical Medicine and Hygiene
record_format MEDLINE/PubMed
spelling pubmed-47519502016-02-22 Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011 Hause, Anne M. Perez-Padilla, Janice Horiuchi, Kalanthe Han, George S. Hunsperger, Elizabeth Aiwazian, Jonathan Margolis, Harold S. Tomashek, Kay M. Am J Trop Med Hyg Articles Dengue, a mosquito-borne viral illness caused by dengue virus types (DENV)-1 to DENV-4, is endemic in Puerto Rico. Severe dengue usually occurs in individuals previously infected with DENV or among infants born to previously infected mothers. To describe clinical features of dengue in infants, we retrospectively characterized dengue patients aged < 18 months reported to the Passive Dengue Surveillance System (PDSS) during 1999–2011. To determine frequency of signs, symptoms, and disease severity, case report forms and medical records were evaluated for patients who tested positive for dengue by reverse transcriptase polymerase chain reaction or anti-DENV immunoglobulin Menzyme-linked immunosorbent assay. Of 4,178 reported patients aged < 18 months, 813 (19%) were laboratory positive. Of these, most had fever (92%), rash (53%), bleeding manifestations (52%), and thrombocytopenia (52%). Medical records were available for 145 (31%) of 472 hospitalized patients, of which 40% had dengue, 23% had dengue with warning signs, and 33% had severe dengue. Mean age of patients with severe dengue was 8 months. Anti-DENV immunoglobulin G (IgG) titers were not statistically different in patients with (50%) and without (59%) severe dengue. In this study, one-third of DENV-infected infants met the severe dengue case definition. The role of maternal anti-DENV IgG in development of severe disease warrants further study in prospective cohorts of mother-infant pairs. The American Society of Tropical Medicine and Hygiene 2016-02-03 /pmc/articles/PMC4751950/ /pubmed/26711519 http://dx.doi.org/10.4269/ajtmh.15-0382 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Hause, Anne M.
Perez-Padilla, Janice
Horiuchi, Kalanthe
Han, George S.
Hunsperger, Elizabeth
Aiwazian, Jonathan
Margolis, Harold S.
Tomashek, Kay M.
Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title_full Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title_fullStr Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title_full_unstemmed Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title_short Epidemiology of Dengue among Children Aged < 18 Months—Puerto Rico, 1999–2011
title_sort epidemiology of dengue among children aged < 18 months—puerto rico, 1999–2011
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751950/
https://www.ncbi.nlm.nih.gov/pubmed/26711519
http://dx.doi.org/10.4269/ajtmh.15-0382
work_keys_str_mv AT hauseannem epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT perezpadillajanice epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT horiuchikalanthe epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT hangeorges epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT hunspergerelizabeth epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT aiwazianjonathan epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT margolisharolds epidemiologyofdengueamongchildrenaged18monthspuertorico19992011
AT tomashekkaym epidemiologyofdengueamongchildrenaged18monthspuertorico19992011