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The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca(2+) dynamics and insulin secretion
Ca(2+) signals are central to the stimulation of insulin secretion from pancreatic β-cells by glucose and other agents, including glucagon-like peptide-1 (GLP-1). Whilst Ca(2+) influx through voltage-gated Ca(2+) channels on the plasma membrane is a key trigger for glucose-stimulated secretion, mobi...
Autores principales: | Cane, Matthew C., Parrington, John, Rorsman, Patrik, Galione, Antony, Rutter, Guy A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751975/ https://www.ncbi.nlm.nih.gov/pubmed/26769314 http://dx.doi.org/10.1016/j.ceca.2015.12.004 |
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