Compensatory Increase of Transglutaminase 2 Is Responsible for Resistance to mTOR Inhibitor Treatment

The mechanistic target of rapamycin complex 1 (mTORC1) plays a crucial role in controlling cell growth and homeostasis. Deregulation of mTOR signaling is frequently observed in some cancers, making it an attractive drug target for cancer therapy. Although mTORC1 inhibitor rapalog-based therapy has s...

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Detalles Bibliográficos
Autores principales: Cao, Jingwen, Huang, Wenlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752276/
https://www.ncbi.nlm.nih.gov/pubmed/26872016
http://dx.doi.org/10.1371/journal.pone.0149388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752276/
https://www.ncbi.nlm.nih.gov/pubmed/26872016
http://dx.doi.org/10.1371/journal.pone.0149388

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