Cargando…
MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses
A prevailing neuroinflammation hypothesis is that increased production of proinflammatory cytokines contributes to progressive neuropathology, secondary to the primary damage caused by a traumatic brain injury (TBI). In support of the hypothesis, post-injury interventions that inhibit the proinflamm...
Autores principales: | Bachstetter, Adam D., Zhou, Zhengqiu, Rowe, Rachel K., Xing, Bin, Goulding, Danielle S., Conley, Alyssa N., Sompol, Pradoldej, Meier, Shelby, Abisambra, Jose F., Lifshitz, Jonathan, Watterson, D. Martin, Van Eldik, Linda J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752278/ https://www.ncbi.nlm.nih.gov/pubmed/26871438 http://dx.doi.org/10.1371/journal.pone.0149451 |
Ejemplares similares
-
Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic
por: Bachstetter, Adam D, et al.
Publicado: (2015) -
Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology
por: Braun, David J., et al.
Publicado: (2022) -
Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes
por: Zhou, Zhengqiu, et al.
Publicado: (2017) -
Ca(2+), Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases
por: Sompol, Pradoldej, et al.
Publicado: (2018) -
Generation and Behavior Characterization of CaMKIIβ Knockout Mice
por: Bachstetter, Adam D., et al.
Publicado: (2014)