Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles

Neisseria meningitidis recruits host human complement inhibitors to its surface to down-regulate complement activation and enhance survival in blood. We have investigated whether such complement inhibitor binding occurs after vaccination with native outer membrane vesicles (nOMVs), and limits immuno...

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Detalles Bibliográficos
Autores principales: Daniels-Treffandier, Helene, de Nie, Karlijn, Marsay, Leanne, Dold, Christina, Sadarangani, Manish, Reyes-Sandoval, Arturo, Langford, Paul R., Wyllie, David, Hill, Fergal, Pollard, Andrew J., Rollier, Christine S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752311/
https://www.ncbi.nlm.nih.gov/pubmed/26871712
http://dx.doi.org/10.1371/journal.pone.0148840

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