Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women

Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced fo...

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Autores principales: Koss, Catherine A., Natureeba, Paul, Nyafwono, Dorcas, Plenty, Albert, Mwesigwa, Julia, Nzarubara, Bridget, Clark, Tamara D., Ruel, Theodore D., Achan, Jane, Charlebois, Edwin D., Cohan, Deborah, Kamya, Moses R., Havlir, Diane V., Young, Sera L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752388/
https://www.ncbi.nlm.nih.gov/pubmed/26397935
http://dx.doi.org/10.1097/QAI.0000000000000860
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author Koss, Catherine A.
Natureeba, Paul
Nyafwono, Dorcas
Plenty, Albert
Mwesigwa, Julia
Nzarubara, Bridget
Clark, Tamara D.
Ruel, Theodore D.
Achan, Jane
Charlebois, Edwin D.
Cohan, Deborah
Kamya, Moses R.
Havlir, Diane V.
Young, Sera L.
author_facet Koss, Catherine A.
Natureeba, Paul
Nyafwono, Dorcas
Plenty, Albert
Mwesigwa, Julia
Nzarubara, Bridget
Clark, Tamara D.
Ruel, Theodore D.
Achan, Jane
Charlebois, Edwin D.
Cohan, Deborah
Kamya, Moses R.
Havlir, Diane V.
Young, Sera L.
author_sort Koss, Catherine A.
collection PubMed
description Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced food insufficiency. In multivariable analysis, food insufficiency [adjusted odds ratio (aOR) 0.38, 95% confidence interval (CI): 0.16 to 0.91], higher pretreatment HIV-1 RNA (aOR 0.55 per 10-fold increase, 95% CI: 0.37 to 0.82), and lopinavir/ritonavir versus efavirenz (aOR 0.49, 95% CI: 0.24 to 0.96) were associated with lower odds of sustained viral suppression. Interventions to address food security may improve virologic outcomes among HIV-infected women.
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spelling pubmed-47523882016-03-19 Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women Koss, Catherine A. Natureeba, Paul Nyafwono, Dorcas Plenty, Albert Mwesigwa, Julia Nzarubara, Bridget Clark, Tamara D. Ruel, Theodore D. Achan, Jane Charlebois, Edwin D. Cohan, Deborah Kamya, Moses R. Havlir, Diane V. Young, Sera L. J Acquir Immune Defic Syndr Clinical Science Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced food insufficiency. In multivariable analysis, food insufficiency [adjusted odds ratio (aOR) 0.38, 95% confidence interval (CI): 0.16 to 0.91], higher pretreatment HIV-1 RNA (aOR 0.55 per 10-fold increase, 95% CI: 0.37 to 0.82), and lopinavir/ritonavir versus efavirenz (aOR 0.49, 95% CI: 0.24 to 0.96) were associated with lower odds of sustained viral suppression. Interventions to address food security may improve virologic outcomes among HIV-infected women. JAIDS Journal of Acquired Immune Deficiency Syndromes 2016-03-01 2016-02-10 /pmc/articles/PMC4752388/ /pubmed/26397935 http://dx.doi.org/10.1097/QAI.0000000000000860 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
spellingShingle Clinical Science
Koss, Catherine A.
Natureeba, Paul
Nyafwono, Dorcas
Plenty, Albert
Mwesigwa, Julia
Nzarubara, Bridget
Clark, Tamara D.
Ruel, Theodore D.
Achan, Jane
Charlebois, Edwin D.
Cohan, Deborah
Kamya, Moses R.
Havlir, Diane V.
Young, Sera L.
Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title_full Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title_fullStr Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title_full_unstemmed Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title_short Brief Report: Food Insufficiency Is Associated With Lack of Sustained Viral Suppression Among HIV-Infected Pregnant and Breastfeeding Ugandan Women
title_sort brief report: food insufficiency is associated with lack of sustained viral suppression among hiv-infected pregnant and breastfeeding ugandan women
topic Clinical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752388/
https://www.ncbi.nlm.nih.gov/pubmed/26397935
http://dx.doi.org/10.1097/QAI.0000000000000860
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