Cargando…

Gene Regulatory Network Inference of Immunoresponsive Gene 1 (IRG1) Identifies Interferon Regulatory Factor 1 (IRF1) as Its Transcriptional Regulator in Mammalian Macrophages

Immunoresponsive gene 1 (IRG1) is one of the highest induced genes in macrophages under pro-inflammatory conditions. Its function has been recently described: it codes for immune-responsive gene 1 protein/cis-aconitic acid decarboxylase (IRG1/CAD), an enzyme catalysing the production of itaconic aci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tallam, Aravind, Perumal, Thaneer M., Antony, Paul M., Jäger, Christian, Fritz, Joëlle V., Vallar, Laurent, Balling, Rudi, del Sol, Antonio, Michelucci, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752512/ https://www.ncbi.nlm.nih.gov/pubmed/26872335 http://dx.doi.org/10.1371/journal.pone.0149050

Ejemplares similares

Heterologous expression of Mus musculus immunoresponsive gene 1 (irg1) in Escherichia coli results in itaconate production
por: Vuoristo, Kiira S., et al.
Publicado: (2015)

Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia
por: Kuo, Ping-Chang, et al.
Publicado: (2021)

Immunoresponse to Gene-Modified Hematopoietic Stem Cells
por: Drysdale, Claire M., et al.
Publicado: (2019)

Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging
por: Gui, Yujuan, et al.
Publicado: (2020)

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection
por: Irving, Aaron T., et al.
Publicado: (2020)

IRF4 and IRGs Delineate Clinically Relevant Gene Expression Signatures in Systemic Lupus Erythematosus and Rheumatoid Arthritis
por: Rodríguez-Carrio, Javier, et al.
Publicado: (2019)

Mitochondrial ACOD1/IRG1 in infection and sterile inflammation()
por: Wu, Runliu, et al.
Publicado: (2022)

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection
por: Maric-Biresev, Jelena, et al.
Publicado: (2016)

Regulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondii
por: Hunn, Julia P, et al.
Publicado: (2008)

Interferon-regulatory factor-1 (IRF1) regulates bevacizumab induced autophagy
por: Liang, Ji, et al.
Publicado: (2015)

Interferon regulatory factor 1 (IRF1) and anti-pathogen innate immune responses
por: Feng, Hui, et al.
Publicado: (2021)

Immunoresponsiveness in endometriosis: implications of estrogenic toxicants.
por: Rier, S E, et al.
Publicado: (1995)

Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
por: Blanco, Jorge C. G., et al.
Publicado: (2000)

A novel role for interferon regulatory factor 1 (IRF1) in regulation of bone metabolism
por: Salem, Sandra, et al.
Publicado: (2014)

Molecular characterization and antiviral effects of canine interferon regulatory factor 1 (CaIRF1)
por: Hao, Xiangqi, et al.
Publicado: (2022)

Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
por: Chen, F., et al.
Publicado: (2022)

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
por: Zhang, Liyuan, et al.
Publicado: (2023)

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells
por: Horiuchi, Makoto, et al.
Publicado: (2011)

Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat
por: Juhász, Angéla, et al.
Publicado: (2018)

The Tumor Necrosis Factor Alpha and Interleukin 6 Auto-paracrine Signaling Loop Controls Mycobacterium avium Infection via Induction of IRF1/IRG1 in Human Primary Macrophages
por: Gidon, Alexandre, et al.
Publicado: (2021)

The Role of Interferon Regulatory Factor-1 (IRF1) in Overcoming Antiestrogen Resistance in the Treatment of Breast Cancer
por: Schwartz, J. L., et al.
Publicado: (2011)

Immune evasion strategy involving propionylation by the KSHV interferon regulatory factor 1 (vIRF1)
por: Shi, Jiale, et al.
Publicado: (2023)

IRGS: an immune-related gene classifier for lung adenocarcinoma prognosis
por: Shi, Xiaoshun, et al.
Publicado: (2020)

An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates
por: Carroll, Shannon H., et al.
Publicado: (2020)

Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms
por: El-Sayed, A
Publicado: (2018)

The STING1-MYD88 complex drives ACOD1/IRG1 expression and function in lethal innate immunity
por: Chen, Feng, et al.
Publicado: (2022)

Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection
por: Nair, Sharmila, et al.
Publicado: (2018)

Tagging Single Nucleotide Polymorphisms in the IRF1 and IRF8 Genes and Tuberculosis Susceptibility
por: Ding, Shiping, et al.
Publicado: (2012)

Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution
por: Huang, Bei, et al.
Publicado: (2010)

Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1)
por: Buro, Lauren J, et al.
Publicado: (2010)

Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles
por: Wang, Menglei, et al.
Publicado: (2018)

Immunoresponsive Tissue-Engineered Oral Mucosal Equivalents Containing Macrophages
por: Ollington, Bethany, et al.
Publicado: (2021)

Detecting cellular reprogramming determinants by differential stability analysis of gene regulatory networks
por: Crespo, Isaac, et al.
Publicado: (2013)

Colocalization of Interferon Regulatory Factor 7 (IRF7) with Latent Membrane Protein 1 (LMP1) of Epstein-Barr Virus
por: Kim, In-Wook, et al.
Publicado: (2006)

Interferon regulatory factor 1 (IRF1) inhibits lung endothelial regeneration following inflammation-induced acute lung injury
por: Chen, Xiaorui, et al.
Publicado: (2023)

Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy
por: Chen, Yu-Jia, et al.
Publicado: (2023)

Phosphorylation of interferon regulatory factor 9 (IRF9)
por: Paul, Alvin, et al.
Publicado: (2023)

Interferon Regulatory Factor-1 (IRF1) activates autophagy to promote liver ischemia/reperfusion injury by inhibiting β-catenin in mice
por: Yan, Bing, et al.
Publicado: (2020)

Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection
por: Schmalzl, Angelika, et al.
Publicado: (2022)

PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells
por: He, Feng, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ma5rtjtg7n0aotvh29bo65mjp1