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Dietary components as epigenetic-regulating agents against cancer

Carcinogenesis is a complicated process that involves the deregulation of epigenetics resulting in cellular transformational events, such proliferation, differentiation, and metastasis. Epigenetic machinery changes the accessibility of chromatin to transcriptional regulation through DNA modification...

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Detalles Bibliográficos
Autores principales: Chang, Ling-Chu, Yu, Yung-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: China Medical University 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752550/
https://www.ncbi.nlm.nih.gov/pubmed/26872811
http://dx.doi.org/10.7603/s40681-016-0002-8
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author Chang, Ling-Chu
Yu, Yung-Luen
author_facet Chang, Ling-Chu
Yu, Yung-Luen
author_sort Chang, Ling-Chu
collection PubMed
description Carcinogenesis is a complicated process that involves the deregulation of epigenetics resulting in cellular transformational events, such proliferation, differentiation, and metastasis. Epigenetic machinery changes the accessibility of chromatin to transcriptional regulation through DNA modification. The collaboration of epigenetics and gene transcriptional regulation creates a suitable microenvironment for cancer development, which is proved by the alternation in cell proliferation, differentiation, division, metabolism, DNA repair and movement. Therefore, the reverse of epigenetic dysfunction may provide a possible strategy and new therapeutic targets for cancer treatment. Many dietary components such as sulforaphane and epigallocatechin- 3-gallate have been demonstrated to exert chemopreventive influences, such as reducing tumor growth and enhancing cancer cell death. Anticancer mechanistic studies also indicated that dietary components could display the ability to reverse epigenetic deregulation in assorted tumors via reverting the adverse epigenetic regulation, including alternation of DNA methylation and histone modification, and modulation of microRNA expression. Therefore, dietary components as therapeutic agents on epigenetics becomes an attractive approach for cancer prevention and intervention at the moment. In this review, we summarize the recent discoveries and underlying mechanisms of the most common dietary components for cancer prevention via epigenetic regulation.
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spelling pubmed-47525502016-02-16 Dietary components as epigenetic-regulating agents against cancer Chang, Ling-Chu Yu, Yung-Luen Biomedicine (Taipei) Review Article Carcinogenesis is a complicated process that involves the deregulation of epigenetics resulting in cellular transformational events, such proliferation, differentiation, and metastasis. Epigenetic machinery changes the accessibility of chromatin to transcriptional regulation through DNA modification. The collaboration of epigenetics and gene transcriptional regulation creates a suitable microenvironment for cancer development, which is proved by the alternation in cell proliferation, differentiation, division, metabolism, DNA repair and movement. Therefore, the reverse of epigenetic dysfunction may provide a possible strategy and new therapeutic targets for cancer treatment. Many dietary components such as sulforaphane and epigallocatechin- 3-gallate have been demonstrated to exert chemopreventive influences, such as reducing tumor growth and enhancing cancer cell death. Anticancer mechanistic studies also indicated that dietary components could display the ability to reverse epigenetic deregulation in assorted tumors via reverting the adverse epigenetic regulation, including alternation of DNA methylation and histone modification, and modulation of microRNA expression. Therefore, dietary components as therapeutic agents on epigenetics becomes an attractive approach for cancer prevention and intervention at the moment. In this review, we summarize the recent discoveries and underlying mechanisms of the most common dietary components for cancer prevention via epigenetic regulation. China Medical University 2016-02-23 /pmc/articles/PMC4752550/ /pubmed/26872811 http://dx.doi.org/10.7603/s40681-016-0002-8 Text en © China Medical University 2016 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided original author(s) and source are credited.
spellingShingle Review Article
Chang, Ling-Chu
Yu, Yung-Luen
Dietary components as epigenetic-regulating agents against cancer
title Dietary components as epigenetic-regulating agents against cancer
title_full Dietary components as epigenetic-regulating agents against cancer
title_fullStr Dietary components as epigenetic-regulating agents against cancer
title_full_unstemmed Dietary components as epigenetic-regulating agents against cancer
title_short Dietary components as epigenetic-regulating agents against cancer
title_sort dietary components as epigenetic-regulating agents against cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752550/
https://www.ncbi.nlm.nih.gov/pubmed/26872811
http://dx.doi.org/10.7603/s40681-016-0002-8
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