Cargando…

Serine-arginine protein kinase 1 (SRPK1), a determinant of angiogenesis, is upregulated in prostate cancer and correlates with disease stage and invasion

Vascular endothelial growth factor (VEGF) undergoes alternative splicing to produce both proangiogenic and antiangiogenic isoforms. Preferential splicing of proangiogenic VEGF is determined by serine-arginine protein kinase 1 (SRPK1), which is upregulated in a number of cancers. In the present study...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bullock, Nicholas, Potts, Jonathan, Simpkin, Andrew J, Koupparis, Anthony, Harper, Steve J, Oxley, Jon, Oltean, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2016
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752636/ https://www.ncbi.nlm.nih.gov/pubmed/26500332 http://dx.doi.org/10.1136/jclinpath-2015-203125

Ejemplares similares

SERINE ARGININE PROTEIN KINASE-1 (SRPK1) INHIBITION AS A POTENTIAL NOVEL TARGETED THERAPEUTIC STRATEGY IN PROSTATE CANCER
por: Mavrou, Athina, et al.
Publicado: (2014)

The many faces of SRPK1
por: Bullock, Nicholas, et al.
Publicado: (2017)

Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions
por: Xu, Xiaotao, et al.
Publicado: (2017)

Serine-Arginine Protein Kinase 1 (SRPK1): a systematic review of its multimodal role in oncogenesis
por: Duggan, William P., et al.
Publicado: (2022)

Impaired expression of serine/arginine protein kinase 2 (SRPK2) affects melanoma progression
por: Caetano, Mônica Maria Magalhães, et al.
Publicado: (2022)

Human papillomavirus type 16 infection activates the host serine arginine protein kinase 1 (SRPK1) – splicing factor axis
por: Mole, Sarah, et al.
Publicado: (2020)

Serine–Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2
por: Arancibia, Duxan, et al.
Publicado: (2019)

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
por: Gammons, M V, et al.
Publicado: (2014)

Serine-Arginine Protein Kinase 1 (SRPK1) as a Prognostic Factor and Potential Therapeutic Target in Cancer: Current Evidence and Future Perspectives
por: Nikas, Ilias P., et al.
Publicado: (2019)

Increased expression of SRPK1 (serine/arginine-rich protein-specific kinase 1) is associated with progression and unfavorable prognosis in cervical squamous cell carcinoma
por: Dong, Zhanfei, et al.
Publicado: (2022)

SRPK1 inhibition in prostate cancer: A novel anti-angiogenic treatment through modulation of VEGF alternative splicing
por: Mavrou, Athina, et al.
Publicado: (2016)

Serine-arginine protein kinase 1 (SRPK1) promotes EGFR-TKI resistance by enhancing GSK3β Ser9 autophosphorylation independent of its kinase activity in non-small-cell lung cancer
por: Huang, Jing-Qiang, et al.
Publicado: (2023)

Recruiting a Silent Partner for Activation of the Protein Kinase SRPK1
por: Aubol, Brandon E., et al.
Publicado: (2014)

Serine-Arginine Protein Kinase 1 Regulates Ebola Virus Transcription
por: Takamatsu, Yuki, et al.
Publicado: (2020)

SRPK1 Dissimilarly Impacts on the Growth, Metastasis, Chemosensitivity and Angiogenesis of Glioma in Normoxic and Hypoxic Conditions
por: Wu, Qianqian, et al.
Publicado: (2013)

Data on the expression of SRPK1a in mammals
por: Vlassi, Metaxia, et al.
Publicado: (2019)

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers
por: Kremer, Jeff Charles, et al.
Publicado: (2017)

Identification of a novel and potent small molecule inhibitor of SRPK1: mechanism of dual inhibition of SRPK1 for the inhibition of cancer progression
por: Chandra, Anshuman, et al.
Publicado: (2020)

Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization
por: Koutroumani, Maria, et al.
Publicado: (2017)

Serine-arginine protein kinases and their targets in viral infection and their inhibition
por: Zheng, Kai, et al.
Publicado: (2023)

Abnormal Expression of the Pre-mRNA Splicing Regulators SRSF1, SRSF2, SRPK1 and SRPK2 in Non Small Cell Lung Carcinoma
por: Gout, Stephanie, et al.
Publicado: (2012)

The conserved kinase SRPK regulates karyosome formation and spindle microtubule assembly in Drosophila oocytes
por: Loh, Benjamin J., et al.
Publicado: (2012)

Knockdown of Serine–Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells
por: Han, Xingtao, et al.
Publicado: (2017)

Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization
por: Dong, Zhenyu, et al.
Publicado: (2013)

FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells
por: Jia, Tao, et al.
Publicado: (2021)

The crucial role of SRPK1 in IGF-1-induced EMT of human gastric cancer
por: Wang, Hong, et al.
Publicado: (2017)

Pathogenic fungi neutralize plant‐derived ROS via Srpk1 deacetylation
por: Zhang, Ning, et al.
Publicado: (2023)

Elevated Expression of the Serine-Arginine Protein Kinase 1 Gene in Ovarian Cancer and Its Role in Cisplatin Cytotoxicity In Vitro
por: Odunsi, Kunle, et al.
Publicado: (2012)

Targeting Angiogenesis in Prostate Cancer
por: Melegh, Zsombor, et al.
Publicado: (2019)

Identification of a nuclear localization motif in the serine/arginine protein kinase PSRPK of physarum polycephalum
por: Liu, Shide, et al.
Publicado: (2009)

USP39 promotes malignant proliferation and angiogenesis of renal cell carcinoma by inhibiting VEGF-A(165b) alternative splicing via regulating SRSF1 and SRPK1
por: Pan, Xiu-wu, et al.
Publicado: (2021)

SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach
por: Voukkalis, Nikolaos, et al.
Publicado: (2016)

LIMK2 promotes the metastatic progression of triple-negative breast cancer by activating SRPK1
por: Malvi, Parmanand, et al.
Publicado: (2020)

SRPK1 acetylation modulates alternative splicing to regulate cisplatin resistance in breast cancer cells
por: Wang, Cheng, et al.
Publicado: (2020)

PfSRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation
por: Kumar, Sudhir, et al.
Publicado: (2022)

Towards understandings of serine/arginine-rich splicing factors
por: Li, Dianyang, et al.
Publicado: (2023)

In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1()
por: Yamaguchi, Akihiko, et al.
Publicado: (2013)

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells
por: Gonçalves, Vânia, et al.
Publicado: (2014)

High Serine-arginine Protein Kinase 1 Expression with PTEN Loss Defines Aggressive Phenotype of Prostate Cancer Associated with Lethal Outcome and Decreased Overall Survival
por: Abou-Ouf, Hatem, et al.
Publicado: (2020)

Bruchpilot in Ribbon-Like Axonal Agglomerates, Behavioral Defects, and Early Death in SRPK79D Kinase Mutants of Drosophila
por: Nieratschker, Vanessa, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_00daggm67ouorb6u6496ho290t