Mechanisms of vascularization in murine models of primary and metastatic tumor growth

Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanism...

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Autores principales: Bugyik, Edina, Renyi-Vamos, Ferenc, Szabo, Vanessza, Dezso, Katalin, Ecker, Nora, Rokusz, Andras, Nagy, Peter, Dome, Balazs, Paku, Sandor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752760/
https://www.ncbi.nlm.nih.gov/pubmed/26873579
http://dx.doi.org/10.1186/s40880-016-0083-5
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author Bugyik, Edina
Renyi-Vamos, Ferenc
Szabo, Vanessza
Dezso, Katalin
Ecker, Nora
Rokusz, Andras
Nagy, Peter
Dome, Balazs
Paku, Sandor
author_facet Bugyik, Edina
Renyi-Vamos, Ferenc
Szabo, Vanessza
Dezso, Katalin
Ecker, Nora
Rokusz, Andras
Nagy, Peter
Dome, Balazs
Paku, Sandor
author_sort Bugyik, Edina
collection PubMed
description Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology.
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spelling pubmed-47527602016-02-22 Mechanisms of vascularization in murine models of primary and metastatic tumor growth Bugyik, Edina Renyi-Vamos, Ferenc Szabo, Vanessza Dezso, Katalin Ecker, Nora Rokusz, Andras Nagy, Peter Dome, Balazs Paku, Sandor Chin J Cancer Review Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vasculature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co-option, and glomeruloid angiogenesis. Importantly, in response to anti-angiogenic therapies, malignant tumors can switch from one vascularization mechanism to another. In this article, we briefly review the biological features of these mechanisms and discuss on their significance in medical oncology. BioMed Central 2016-02-12 /pmc/articles/PMC4752760/ /pubmed/26873579 http://dx.doi.org/10.1186/s40880-016-0083-5 Text en © Bugyik et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Bugyik, Edina
Renyi-Vamos, Ferenc
Szabo, Vanessza
Dezso, Katalin
Ecker, Nora
Rokusz, Andras
Nagy, Peter
Dome, Balazs
Paku, Sandor
Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title_full Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title_fullStr Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title_full_unstemmed Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title_short Mechanisms of vascularization in murine models of primary and metastatic tumor growth
title_sort mechanisms of vascularization in murine models of primary and metastatic tumor growth
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752760/
https://www.ncbi.nlm.nih.gov/pubmed/26873579
http://dx.doi.org/10.1186/s40880-016-0083-5
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