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Select Bcl-2 antagonism restores chemotherapy sensitivity in high-risk neuroblastoma

BACKGROUND: Pediatric patients with high-risk neuroblastoma (HR NB) often fail to respond to upfront intensive multimodal therapy. Tumor-acquired suppression of apoptosis contributes to therapy resistance. Many HR NB tumors depend on the anti-apoptotic protein Bcl-2 for survival, through Bcl-2 seque...

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Detalles Bibliográficos
Autores principales:	Tanos, Rachel, Karmali, Dipan, Nalluri, Srilatha, Goldsmith, Kelly C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752777/ https://www.ncbi.nlm.nih.gov/pubmed/26874859 http://dx.doi.org/10.1186/s12885-016-2129-0

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