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Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial
BACKGROUND: Migraine is one of the most common and debilitating neurological problems. Although numerous preventive drugs are used to treat migraine, their complications are unavoidable. Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like mi...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752800/ https://www.ncbi.nlm.nih.gov/pubmed/26889386 http://dx.doi.org/10.5812/ircmj.20759 |
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author | Delavar Kasmaei, Hosein Ghorbanifar, Zahra Zayeri, Farid Minaei, Bagher Kamali, Seyed Hamid Rezaeizadeh, Hossein Amin, Gholamreza Ghobadi, Ali Mirzaei, Zohreh |
author_facet | Delavar Kasmaei, Hosein Ghorbanifar, Zahra Zayeri, Farid Minaei, Bagher Kamali, Seyed Hamid Rezaeizadeh, Hossein Amin, Gholamreza Ghobadi, Ali Mirzaei, Zohreh |
author_sort | Delavar Kasmaei, Hosein |
collection | PubMed |
description | BACKGROUND: Migraine is one of the most common and debilitating neurological problems. Although numerous preventive drugs are used to treat migraine, their complications are unavoidable. Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like migraine, could be effective. Coriandrum sativum L. (C. sativum) fruit is one of the most commonly prescribed herbs in Persian medicine, which has been used to treat headache. OBJECTIVES: This study was designed to evaluate the effects of C. sativum syrup on duration, severity and frequency of migraine. PATIENTS AND METHODS: A total of 68 migraineurs, who had the eligibility criteria, according to international headache society diagnostic criteria, were randomly assigned to intervention group (n = 34) or control group (n = 34). In addition to 500 mg of sodium valproate per day, in intervention group, they received 15 mL of Coriander fruit syrup and 15 mL of placebo syrup, in control group, three times a day, during a month. The subjects were followed for clinical efficacy at weeks 1, 2, 3 and 4. The number of migraine attacks per week, as well as the duration and severity of attacks, were evaluated. RESULTS: Of 68 patients randomized, 66 were included in analysis. The generalized estimating equations analysis showed that the Coriander fruit syrup decreased duration, severity and frequency of migraine, in the intervention group (P < 0.001). To be more precise, the mean migraine duration, severity and frequency, in the intervention group, were 5.7 hours, 3.65 units and about 50% less than control group, respectively. CONCLUSIONS: Results of this study showed that C. sativum fruit is efficient in reduction of the duration and frequency of migraine attacks and in diminishing pain degree. |
format | Online Article Text |
id | pubmed-4752800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-47528002016-02-17 Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial Delavar Kasmaei, Hosein Ghorbanifar, Zahra Zayeri, Farid Minaei, Bagher Kamali, Seyed Hamid Rezaeizadeh, Hossein Amin, Gholamreza Ghobadi, Ali Mirzaei, Zohreh Iran Red Crescent Med J Research Article BACKGROUND: Migraine is one of the most common and debilitating neurological problems. Although numerous preventive drugs are used to treat migraine, their complications are unavoidable. Application of herbal medicine, especially well-known medicinal plants, to treatment of chronic diseases, like migraine, could be effective. Coriandrum sativum L. (C. sativum) fruit is one of the most commonly prescribed herbs in Persian medicine, which has been used to treat headache. OBJECTIVES: This study was designed to evaluate the effects of C. sativum syrup on duration, severity and frequency of migraine. PATIENTS AND METHODS: A total of 68 migraineurs, who had the eligibility criteria, according to international headache society diagnostic criteria, were randomly assigned to intervention group (n = 34) or control group (n = 34). In addition to 500 mg of sodium valproate per day, in intervention group, they received 15 mL of Coriander fruit syrup and 15 mL of placebo syrup, in control group, three times a day, during a month. The subjects were followed for clinical efficacy at weeks 1, 2, 3 and 4. The number of migraine attacks per week, as well as the duration and severity of attacks, were evaluated. RESULTS: Of 68 patients randomized, 66 were included in analysis. The generalized estimating equations analysis showed that the Coriander fruit syrup decreased duration, severity and frequency of migraine, in the intervention group (P < 0.001). To be more precise, the mean migraine duration, severity and frequency, in the intervention group, were 5.7 hours, 3.65 units and about 50% less than control group, respectively. CONCLUSIONS: Results of this study showed that C. sativum fruit is efficient in reduction of the duration and frequency of migraine attacks and in diminishing pain degree. Kowsar 2016-01-02 /pmc/articles/PMC4752800/ /pubmed/26889386 http://dx.doi.org/10.5812/ircmj.20759 Text en Copyright © 2016, Iranian Red Crescent Medical Journal. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Delavar Kasmaei, Hosein Ghorbanifar, Zahra Zayeri, Farid Minaei, Bagher Kamali, Seyed Hamid Rezaeizadeh, Hossein Amin, Gholamreza Ghobadi, Ali Mirzaei, Zohreh Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title | Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title_full | Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title_fullStr | Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title_full_unstemmed | Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title_short | Effects of Coriandrum sativum Syrup on Migraine: A Randomized, Triple-Blind, Placebo-Controlled Trial |
title_sort | effects of coriandrum sativum syrup on migraine: a randomized, triple-blind, placebo-controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752800/ https://www.ncbi.nlm.nih.gov/pubmed/26889386 http://dx.doi.org/10.5812/ircmj.20759 |
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