Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone protei...

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Detalles Bibliográficos
Autores principales: McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964/
https://www.ncbi.nlm.nih.gov/pubmed/26646779
http://dx.doi.org/10.1007/s00401-015-1508-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752964/
https://www.ncbi.nlm.nih.gov/pubmed/26646779
http://dx.doi.org/10.1007/s00401-015-1508-y

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