Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt

Lipopolysaccharide (LPS) and endothelin- (ET-) 1 may aggravate portal hypertension by increasing intrahepatic resistance and splanchnic blood flow. In the portal vein, after TIPS shunting, LPS and ET-1 were significantly decreased. Our study suggests that TIPS can benefit cirrhotic patients not only...

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Detalles Bibliográficos
Autores principales: Meng, Jiaxiang, Wang, Qing, Liu, Kai, Yang, Shuofei, Fan, Xinxin, Liu, Baochen, He, Changsheng, Wu, Xingjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753051/
https://www.ncbi.nlm.nih.gov/pubmed/26941788
http://dx.doi.org/10.1155/2016/8341030
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author Meng, Jiaxiang
Wang, Qing
Liu, Kai
Yang, Shuofei
Fan, Xinxin
Liu, Baochen
He, Changsheng
Wu, Xingjiang
author_facet Meng, Jiaxiang
Wang, Qing
Liu, Kai
Yang, Shuofei
Fan, Xinxin
Liu, Baochen
He, Changsheng
Wu, Xingjiang
author_sort Meng, Jiaxiang
collection PubMed
description Lipopolysaccharide (LPS) and endothelin- (ET-) 1 may aggravate portal hypertension by increasing intrahepatic resistance and splanchnic blood flow. In the portal vein, after TIPS shunting, LPS and ET-1 were significantly decreased. Our study suggests that TIPS can benefit cirrhotic patients not only in high hemodynamics related variceal bleeding but also in intestinal bacterial translocation associated complications such as endotoxemia.
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spelling pubmed-47530512016-03-03 Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt Meng, Jiaxiang Wang, Qing Liu, Kai Yang, Shuofei Fan, Xinxin Liu, Baochen He, Changsheng Wu, Xingjiang Gastroenterol Res Pract Research Article Lipopolysaccharide (LPS) and endothelin- (ET-) 1 may aggravate portal hypertension by increasing intrahepatic resistance and splanchnic blood flow. In the portal vein, after TIPS shunting, LPS and ET-1 were significantly decreased. Our study suggests that TIPS can benefit cirrhotic patients not only in high hemodynamics related variceal bleeding but also in intestinal bacterial translocation associated complications such as endotoxemia. Hindawi Publishing Corporation 2016 2016-01-31 /pmc/articles/PMC4753051/ /pubmed/26941788 http://dx.doi.org/10.1155/2016/8341030 Text en Copyright © 2016 Jiaxiang Meng et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Meng, Jiaxiang
Wang, Qing
Liu, Kai
Yang, Shuofei
Fan, Xinxin
Liu, Baochen
He, Changsheng
Wu, Xingjiang
Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title_full Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title_fullStr Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title_full_unstemmed Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title_short Systemic and Splanchnic Lipopolysaccharide and Endothelin-1 Plasma Levels in Liver Cirrhosis before and after Transjugular Intrahepatic Portosystemic Shunt
title_sort systemic and splanchnic lipopolysaccharide and endothelin-1 plasma levels in liver cirrhosis before and after transjugular intrahepatic portosystemic shunt
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753051/
https://www.ncbi.nlm.nih.gov/pubmed/26941788
http://dx.doi.org/10.1155/2016/8341030
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