H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

Regions of hypoxia occur in most solid tumors, and they are associated with a poor prognostic outcome. Despite the absence of detectable DNA damage, severe hypoxia (<0.1% O(2)) induces a DNA damage response, including the activation of p53 and subsequent induction of p53-dependent apoptosis. Fact...

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Detalles Bibliográficos
Autores principales: Olcina, M M, Leszczynska, K B, Senra, J M, Isa, N F, Harada, H, Hammond, E M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753255/
https://www.ncbi.nlm.nih.gov/pubmed/25961932
http://dx.doi.org/10.1038/onc.2015.134

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