Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine

Lidocaine bears in its structure both an aromatic ring and a terminal amine, which can be protonated at physiological pH, linked by an amide group. Since lidocaine causes multiple inhibitory actions on nicotinic acetylcholine receptors (nAChRs), this work was aimed to determine the inhibitory effect...

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Detalles Bibliográficos
Autores principales: Alberola-Die, Armando, Fernández-Ballester, Gregorio, González-Ros, José M., Ivorra, Isabel, Morales, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753328/
https://www.ncbi.nlm.nih.gov/pubmed/26912995
http://dx.doi.org/10.3389/fnmol.2016.00012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753328/
https://www.ncbi.nlm.nih.gov/pubmed/26912995
http://dx.doi.org/10.3389/fnmol.2016.00012

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