Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1

In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretrovi...

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Autores principales: Béguelin, C., Vázquez, M., Bertschi, M., Yerly, S., de Jong, D., Gutbrod, K., Rauch, A., Cusini, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753349/
https://www.ncbi.nlm.nih.gov/pubmed/26885540
http://dx.doi.org/10.1093/ofid/ofv210
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author Béguelin, C.
Vázquez, M.
Bertschi, M.
Yerly, S.
de Jong, D.
Gutbrod, K.
Rauch, A.
Cusini, A.
author_facet Béguelin, C.
Vázquez, M.
Bertschi, M.
Yerly, S.
de Jong, D.
Gutbrod, K.
Rauch, A.
Cusini, A.
author_sort Béguelin, C.
collection PubMed
description In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms.
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spelling pubmed-47533492016-02-16 Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1 Béguelin, C. Vázquez, M. Bertschi, M. Yerly, S. de Jong, D. Gutbrod, K. Rauch, A. Cusini, A. Open Forum Infect Dis Brief Reports In this study, we report the case of a patient infected with human immunodeficiency virus (HIV)-1 who developed ataxia and neurocognitive impairment due to viral escape within the central nervous system (CNS) with a multidrug-resistant HIV-1 despite long-term viral suppression in plasma. Antiretroviral therapy optimization with drugs with high CNS penetration led to viral suppression in the CSF, regression of ataxia, and improvement of neurocognitive symptoms. Oxford University Press 2015-12-28 /pmc/articles/PMC4753349/ /pubmed/26885540 http://dx.doi.org/10.1093/ofid/ofv210 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Béguelin, C.
Vázquez, M.
Bertschi, M.
Yerly, S.
de Jong, D.
Gutbrod, K.
Rauch, A.
Cusini, A.
Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title_full Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title_fullStr Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title_full_unstemmed Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title_short Viral Escape in the Central Nervous System with Multidrug-Resistant Human Immunodeficiency Virus-1
title_sort viral escape in the central nervous system with multidrug-resistant human immunodeficiency virus-1
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753349/
https://www.ncbi.nlm.nih.gov/pubmed/26885540
http://dx.doi.org/10.1093/ofid/ofv210
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