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What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts

OBJECTIVE: South Asians are a high-risk group for type 2 diabetes and coronary heart disease. We sought to determine ethnic differences in newborn adiposity comparing South Asians (SA) to White Caucasians (Whites). METHODS: Seven hundred ninety pregnant women (401 SA, 389 Whites) and their full-term...

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Autores principales: Anand, S S, Gupta, M K, Schulze, K M, Desai, D, Abdalla, N, Wahi, G, Wade, C, Scheufler, P, McDonald, S D, Morrison, K M, Vasudevan, A, Dwarakanath, P, Srinivasan, K, Kurpad, A, Gerstein, H C, Teo, K K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753357/
https://www.ncbi.nlm.nih.gov/pubmed/26315840
http://dx.doi.org/10.1038/ijo.2015.171
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author Anand, S S
Gupta, M K
Schulze, K M
Desai, D
Abdalla, N
Wahi, G
Wade, C
Scheufler, P
McDonald, S D
Morrison, K M
Vasudevan, A
Dwarakanath, P
Srinivasan, K
Kurpad, A
Gerstein, H C
Teo, K K
author_facet Anand, S S
Gupta, M K
Schulze, K M
Desai, D
Abdalla, N
Wahi, G
Wade, C
Scheufler, P
McDonald, S D
Morrison, K M
Vasudevan, A
Dwarakanath, P
Srinivasan, K
Kurpad, A
Gerstein, H C
Teo, K K
author_sort Anand, S S
collection PubMed
description OBJECTIVE: South Asians are a high-risk group for type 2 diabetes and coronary heart disease. We sought to determine ethnic differences in newborn adiposity comparing South Asians (SA) to White Caucasians (Whites). METHODS: Seven hundred ninety pregnant women (401 SA, 389 Whites) and their full-term offspring from two birth cohorts in Canada were analyzed. Pregnant women completed a health assessment including a 75-g oral glucose tolerance test to assess for dysglycemia. Birthweight, length, waist and hip circumference, and triceps and subscapular skinfold thickness (a surrogate measure of body adiposity) were measured in all newborns. Multivariate regression was used to identify maternal factors associated with newborn skinfold measurements. RESULTS: South Asian women were younger (30.1 vs 31.8 years, P<0.001), their prepregnancy body mass index was lower (23.7 vs 26.2, P<0.0001) and gestational diabetes was substantially higher (21% vs 13%, P=0.005) compared with Whites. Among full-term newborns, South Asians had lower birthweight (3283 vs 3517 g, P=0.0001), had greater skinfold thickness (11.7 vs 10.6 mm; P=0.0001) and higher waist circumference (31.1 vs 29.9 cm, P=0.0001) compared with Whites. Risk factors for newborn skinfold thickness included South Asian ethnicity (standardized estimate (s.e.): 0.24; P<0.0001), maternal glucose (s.e.: 0.079; P=0.04) and maternal body fat (s.e.: 0.14; P=0.0002). CONCLUSIONS: South Asian newborns are lower birthweight and have greater skinfold thickness, compared with White newborns, and this is influenced by maternal body fat and glucose. Interventions aimed at reducing body fat prior to pregnancy and gestational diabetes during pregnancy in South Asians may favorably alter newborn body composition and require evaluation.
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spelling pubmed-47533572016-03-02 What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts Anand, S S Gupta, M K Schulze, K M Desai, D Abdalla, N Wahi, G Wade, C Scheufler, P McDonald, S D Morrison, K M Vasudevan, A Dwarakanath, P Srinivasan, K Kurpad, A Gerstein, H C Teo, K K Int J Obes (Lond) Original Article OBJECTIVE: South Asians are a high-risk group for type 2 diabetes and coronary heart disease. We sought to determine ethnic differences in newborn adiposity comparing South Asians (SA) to White Caucasians (Whites). METHODS: Seven hundred ninety pregnant women (401 SA, 389 Whites) and their full-term offspring from two birth cohorts in Canada were analyzed. Pregnant women completed a health assessment including a 75-g oral glucose tolerance test to assess for dysglycemia. Birthweight, length, waist and hip circumference, and triceps and subscapular skinfold thickness (a surrogate measure of body adiposity) were measured in all newborns. Multivariate regression was used to identify maternal factors associated with newborn skinfold measurements. RESULTS: South Asian women were younger (30.1 vs 31.8 years, P<0.001), their prepregnancy body mass index was lower (23.7 vs 26.2, P<0.0001) and gestational diabetes was substantially higher (21% vs 13%, P=0.005) compared with Whites. Among full-term newborns, South Asians had lower birthweight (3283 vs 3517 g, P=0.0001), had greater skinfold thickness (11.7 vs 10.6 mm; P=0.0001) and higher waist circumference (31.1 vs 29.9 cm, P=0.0001) compared with Whites. Risk factors for newborn skinfold thickness included South Asian ethnicity (standardized estimate (s.e.): 0.24; P<0.0001), maternal glucose (s.e.: 0.079; P=0.04) and maternal body fat (s.e.: 0.14; P=0.0002). CONCLUSIONS: South Asian newborns are lower birthweight and have greater skinfold thickness, compared with White newborns, and this is influenced by maternal body fat and glucose. Interventions aimed at reducing body fat prior to pregnancy and gestational diabetes during pregnancy in South Asians may favorably alter newborn body composition and require evaluation. Nature Publishing Group 2016-02 2015-09-29 /pmc/articles/PMC4753357/ /pubmed/26315840 http://dx.doi.org/10.1038/ijo.2015.171 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Original Article
Anand, S S
Gupta, M K
Schulze, K M
Desai, D
Abdalla, N
Wahi, G
Wade, C
Scheufler, P
McDonald, S D
Morrison, K M
Vasudevan, A
Dwarakanath, P
Srinivasan, K
Kurpad, A
Gerstein, H C
Teo, K K
What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title_full What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title_fullStr What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title_full_unstemmed What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title_short What accounts for ethnic differences in newborn skinfold thickness comparing South Asians and White Caucasians? Findings from the START and FAMILY Birth Cohorts
title_sort what accounts for ethnic differences in newborn skinfold thickness comparing south asians and white caucasians? findings from the start and family birth cohorts
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753357/
https://www.ncbi.nlm.nih.gov/pubmed/26315840
http://dx.doi.org/10.1038/ijo.2015.171
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