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Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder

Recent studies have reported that methylation of the brain-derived neurotrophic factor (BDNF) gene promoter is associated with major depressive disorder (MDD). This study aimed to investigate the association between cortical thickness and methylation of BDNF promoters as well as serum BDNF levels in...

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Autores principales: Na, Kyoung-Sae, Won, Eunsoo, Kang, June, Chang, Hun Soo, Yoon, Ho-Kyoung, Tae, Woo Suk, Kim, Yong-Ku, Lee, Min-Soo, Joe, Sook-Haeng, Kim, Hyun, Ham, Byung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753411/
https://www.ncbi.nlm.nih.gov/pubmed/26876488
http://dx.doi.org/10.1038/srep21089
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author Na, Kyoung-Sae
Won, Eunsoo
Kang, June
Chang, Hun Soo
Yoon, Ho-Kyoung
Tae, Woo Suk
Kim, Yong-Ku
Lee, Min-Soo
Joe, Sook-Haeng
Kim, Hyun
Ham, Byung-Joo
author_facet Na, Kyoung-Sae
Won, Eunsoo
Kang, June
Chang, Hun Soo
Yoon, Ho-Kyoung
Tae, Woo Suk
Kim, Yong-Ku
Lee, Min-Soo
Joe, Sook-Haeng
Kim, Hyun
Ham, Byung-Joo
author_sort Na, Kyoung-Sae
collection PubMed
description Recent studies have reported that methylation of the brain-derived neurotrophic factor (BDNF) gene promoter is associated with major depressive disorder (MDD). This study aimed to investigate the association between cortical thickness and methylation of BDNF promoters as well as serum BDNF levels in MDD. The participants consisted of 65 patients with recurrent MDD and 65 age- and gender-matched healthy controls. Methylation of BDNF promoters and cortical thickness were compared between the groups. The right medial orbitofrontal, right lingual, right lateral occipital, left lateral orbitofrontal, left pars triangularis, and left lingual cortices were thinner in patients with MDD than in healthy controls. Among the MDD group, right pericalcarine, right medical orbitofrontal, right rostral middle frontal, right postcentral, right inferior temporal, right cuneus, right precuneus, left frontal pole, left superior frontal, left superior temporal, left rostral middle frontal and left lingual cortices had inverse correlations with methylation of BDNF promoters. Higher levels of BDNF promoter methylation may be closely associated with the reduced cortical thickness among patients with MDD. Serum BDNF levels were significantly lower in MDD, and showed an inverse relationship with BDNF methylation only in healthy controls. Particularly the prefrontal and occipital cortices seem to indicate key regions in which BDNF methylation has a significant effect on structure.
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spelling pubmed-47534112016-02-23 Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder Na, Kyoung-Sae Won, Eunsoo Kang, June Chang, Hun Soo Yoon, Ho-Kyoung Tae, Woo Suk Kim, Yong-Ku Lee, Min-Soo Joe, Sook-Haeng Kim, Hyun Ham, Byung-Joo Sci Rep Article Recent studies have reported that methylation of the brain-derived neurotrophic factor (BDNF) gene promoter is associated with major depressive disorder (MDD). This study aimed to investigate the association between cortical thickness and methylation of BDNF promoters as well as serum BDNF levels in MDD. The participants consisted of 65 patients with recurrent MDD and 65 age- and gender-matched healthy controls. Methylation of BDNF promoters and cortical thickness were compared between the groups. The right medial orbitofrontal, right lingual, right lateral occipital, left lateral orbitofrontal, left pars triangularis, and left lingual cortices were thinner in patients with MDD than in healthy controls. Among the MDD group, right pericalcarine, right medical orbitofrontal, right rostral middle frontal, right postcentral, right inferior temporal, right cuneus, right precuneus, left frontal pole, left superior frontal, left superior temporal, left rostral middle frontal and left lingual cortices had inverse correlations with methylation of BDNF promoters. Higher levels of BDNF promoter methylation may be closely associated with the reduced cortical thickness among patients with MDD. Serum BDNF levels were significantly lower in MDD, and showed an inverse relationship with BDNF methylation only in healthy controls. Particularly the prefrontal and occipital cortices seem to indicate key regions in which BDNF methylation has a significant effect on structure. Nature Publishing Group 2016-02-15 /pmc/articles/PMC4753411/ /pubmed/26876488 http://dx.doi.org/10.1038/srep21089 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Na, Kyoung-Sae
Won, Eunsoo
Kang, June
Chang, Hun Soo
Yoon, Ho-Kyoung
Tae, Woo Suk
Kim, Yong-Ku
Lee, Min-Soo
Joe, Sook-Haeng
Kim, Hyun
Ham, Byung-Joo
Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title_full Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title_fullStr Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title_full_unstemmed Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title_short Brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
title_sort brain-derived neurotrophic factor promoter methylation and cortical thickness in recurrent major depressive disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753411/
https://www.ncbi.nlm.nih.gov/pubmed/26876488
http://dx.doi.org/10.1038/srep21089
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