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Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis

The relationships between polymorphisms of the trans-membrane(TM) region located in the major histocompatibility complex (MHC) class I chain–related gene A (MICA) and Behcet’s disease (BD) have been discussed previously, however, the results were contradictory. In this study, we thoroughly assess wh...

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Autores principales: Zhang, Jun, Liao, Dan, Yang, Lu, Hou, Shengping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753467/
https://www.ncbi.nlm.nih.gov/pubmed/26875668
http://dx.doi.org/10.1038/srep21033
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author Zhang, Jun
Liao, Dan
Yang, Lu
Hou, Shengping
author_facet Zhang, Jun
Liao, Dan
Yang, Lu
Hou, Shengping
author_sort Zhang, Jun
collection PubMed
description The relationships between polymorphisms of the trans-membrane(TM) region located in the major histocompatibility complex (MHC) class I chain–related gene A (MICA) and Behcet’s disease (BD) have been discussed previously, however, the results were contradictory. In this study, we thoroughly assess whether MICA-TM gene variants are associated with BD by means of a systematic review and meta-analysis. Our study focused on the effects of polymorphisms of MICA-A4, A5, A5.1, A6, and A9 from the included articles. Sixteen previous original publications representing 1,555 BD patients and 2,086 unrelated healthy controls analyzed the association of BD with MICA-TM gene polymorphisms. For the five alleles, MICA-A6 showed a strongly positive correlation with BD patients and could be viewed as an increased risk factor of BD (OR = 2.34, 95%CI: 2.02–2.70). Furthermore, MICA-A4, A5, A5.1, and A9 exhibited negative associations with BD (OR = 0.71, 95%CI: 0.58–0.86; OR = 0.75, 95%CI: 0.63–0.90; OR = 0.63, 95%CI: 0.44–0.91; OR = 0.70, 95%CI: 0.58–0.84, respectively). Our meta-analysis confirmed MICA-A6 could be responsible for BD in three ethnic regions and should probably be treated as a risk factor for BD. MICA-A4, A5, A5.1, and A9 could be regarded as protective factors, especially in the Middle East and East Asia.
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spelling pubmed-47534672016-02-23 Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis Zhang, Jun Liao, Dan Yang, Lu Hou, Shengping Sci Rep Article The relationships between polymorphisms of the trans-membrane(TM) region located in the major histocompatibility complex (MHC) class I chain–related gene A (MICA) and Behcet’s disease (BD) have been discussed previously, however, the results were contradictory. In this study, we thoroughly assess whether MICA-TM gene variants are associated with BD by means of a systematic review and meta-analysis. Our study focused on the effects of polymorphisms of MICA-A4, A5, A5.1, A6, and A9 from the included articles. Sixteen previous original publications representing 1,555 BD patients and 2,086 unrelated healthy controls analyzed the association of BD with MICA-TM gene polymorphisms. For the five alleles, MICA-A6 showed a strongly positive correlation with BD patients and could be viewed as an increased risk factor of BD (OR = 2.34, 95%CI: 2.02–2.70). Furthermore, MICA-A4, A5, A5.1, and A9 exhibited negative associations with BD (OR = 0.71, 95%CI: 0.58–0.86; OR = 0.75, 95%CI: 0.63–0.90; OR = 0.63, 95%CI: 0.44–0.91; OR = 0.70, 95%CI: 0.58–0.84, respectively). Our meta-analysis confirmed MICA-A6 could be responsible for BD in three ethnic regions and should probably be treated as a risk factor for BD. MICA-A4, A5, A5.1, and A9 could be regarded as protective factors, especially in the Middle East and East Asia. Nature Publishing Group 2016-02-15 /pmc/articles/PMC4753467/ /pubmed/26875668 http://dx.doi.org/10.1038/srep21033 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Jun
Liao, Dan
Yang, Lu
Hou, Shengping
Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title_full Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title_fullStr Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title_full_unstemmed Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title_short Association between Functional MICA-TM and Behcet’s Disease: A Systematic Review and Meta-analysis
title_sort association between functional mica-tm and behcet’s disease: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753467/
https://www.ncbi.nlm.nih.gov/pubmed/26875668
http://dx.doi.org/10.1038/srep21033
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