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Genetic engineering and heterologous expression of the disorazol biosynthetic gene cluster via Red/ET recombineering

Disorazol, a macrocyclic polykitide produced by the myxobacterium Sorangium cellulosum So ce12 and it is reported to have potential cytotoxic activity towards several cancer cell lines, including multi-drug resistant cells. The disorazol biosynthetic gene cluster (dis) from Sorangium cellulosum (So...

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Detalles Bibliográficos
Autores principales:	Tu, Qiang, Herrmann, Jennifer, Hu, Shengbiao, Raju, Ritesh, Bian, Xiaoying, Zhang, Youming, Müller, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753468/ https://www.ncbi.nlm.nih.gov/pubmed/26875499 http://dx.doi.org/10.1038/srep21066

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