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A Paclitaxel-Loaded Recombinant Polypeptide Nanoparticle Outperforms Abraxane in Multiple Murine Cancer Models

Packaging clinically relevant hydrophobic drugs into a self-assembled nanoparticle can improve their aqueous solubility, plasma half-life, tumor specific uptake and therapeutic potential. To this end, here we conjugated paclitaxel (PTX) to recombinant chimeric polypeptides (CPs) that spontaneously s...

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Detalles Bibliográficos
Autores principales:	Bhattacharyya, Jayanta, Bellucci, Joseph J., Weitzhandler, Isaac, McDaniel, Jonathan R., Spasojevic, Ivan, Li, Xinghai, Lin, Chao-Chieh, Chi, Jen-Tsan Ashley, Chilkoti, Ashutosh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753781/ https://www.ncbi.nlm.nih.gov/pubmed/26239362 http://dx.doi.org/10.1038/ncomms8939

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