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Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study

Renal biopsy remains the golden standard diagnosis of renal function deterioration. The safety in native kidney biopsy is well defined. However, it is a different story in allograft kidney biopsy. We conduct this retrospective study to clarify the safety of allograft kidney biopsy with indication. A...

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Autores principales: Tsai, Shang-Feng, Chen, Cheng-Hsu, Shu, Kuo-Hsiung, Cheng, Chi-Hung, Yu, Tung-Min, Chuang, Ya-Wen, Huang, Shih-Ting, Tsai, Jun-Li, Wu, Ming-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753949/
https://www.ncbi.nlm.nih.gov/pubmed/26871853
http://dx.doi.org/10.1097/MD.0000000000002816
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author Tsai, Shang-Feng
Chen, Cheng-Hsu
Shu, Kuo-Hsiung
Cheng, Chi-Hung
Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Tsai, Jun-Li
Wu, Ming-Ju
author_facet Tsai, Shang-Feng
Chen, Cheng-Hsu
Shu, Kuo-Hsiung
Cheng, Chi-Hung
Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Tsai, Jun-Li
Wu, Ming-Ju
author_sort Tsai, Shang-Feng
collection PubMed
description Renal biopsy remains the golden standard diagnosis of renal function deterioration. The safety in native kidney biopsy is well defined. However, it is a different story in allograft kidney biopsy. We conduct this retrospective study to clarify the safety of allograft kidney biopsy with indication. All variables were grouped by the year of biopsy and they were compared by Mann–Whitney U test (for continuous variables) or Chi-square test (for categorical variables). We collected possible factors associated with complications, including age, gender, body weight, renal function, cause of uremia, status of coagulation, hepatitis, size of needle, and immunosuppressants. We recruited all renal transplant recipients undergoing allograft biopsy between January of 2009 and December of 2014. This is the largest database for allograft kidney biopsy with indication. Of all the 269 biopsies, there was no difference in occurrence among the total 14 complications (5.2%) over these 6 years. There were only 3 cases of hematomas (1.11%), 6 gross hematuria (2.23%), 1 hydronephrosis (0.37%), and 2 hemoglobin decline (0.74%). The outcome of this cohort is the best compared to all other studies, and it is even better than the allograft protocol kidney biopsy. Among all possible factors, patients with pathological report containing “medullary tissue only” were susceptible to complications (P < 0.001, 1.8 of relative risk). In modern era, this study demonstrates the safety of allograft kidney biopsy with indication. Identifying the renal capsule before biopsy to avoid puncture into medulla is the most important element to prevent complications.
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spelling pubmed-47539492016-02-26 Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study Tsai, Shang-Feng Chen, Cheng-Hsu Shu, Kuo-Hsiung Cheng, Chi-Hung Yu, Tung-Min Chuang, Ya-Wen Huang, Shih-Ting Tsai, Jun-Li Wu, Ming-Ju Medicine (Baltimore) 5200 Renal biopsy remains the golden standard diagnosis of renal function deterioration. The safety in native kidney biopsy is well defined. However, it is a different story in allograft kidney biopsy. We conduct this retrospective study to clarify the safety of allograft kidney biopsy with indication. All variables were grouped by the year of biopsy and they were compared by Mann–Whitney U test (for continuous variables) or Chi-square test (for categorical variables). We collected possible factors associated with complications, including age, gender, body weight, renal function, cause of uremia, status of coagulation, hepatitis, size of needle, and immunosuppressants. We recruited all renal transplant recipients undergoing allograft biopsy between January of 2009 and December of 2014. This is the largest database for allograft kidney biopsy with indication. Of all the 269 biopsies, there was no difference in occurrence among the total 14 complications (5.2%) over these 6 years. There were only 3 cases of hematomas (1.11%), 6 gross hematuria (2.23%), 1 hydronephrosis (0.37%), and 2 hemoglobin decline (0.74%). The outcome of this cohort is the best compared to all other studies, and it is even better than the allograft protocol kidney biopsy. Among all possible factors, patients with pathological report containing “medullary tissue only” were susceptible to complications (P < 0.001, 1.8 of relative risk). In modern era, this study demonstrates the safety of allograft kidney biopsy with indication. Identifying the renal capsule before biopsy to avoid puncture into medulla is the most important element to prevent complications. Wolters Kluwer Health 2016-02-12 /pmc/articles/PMC4753949/ /pubmed/26871853 http://dx.doi.org/10.1097/MD.0000000000002816 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5200
Tsai, Shang-Feng
Chen, Cheng-Hsu
Shu, Kuo-Hsiung
Cheng, Chi-Hung
Yu, Tung-Min
Chuang, Ya-Wen
Huang, Shih-Ting
Tsai, Jun-Li
Wu, Ming-Ju
Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title_full Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title_fullStr Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title_full_unstemmed Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title_short Current Safety of Renal Allograft Biopsy With Indication in Adult Recipients: An Observational Study
title_sort current safety of renal allograft biopsy with indication in adult recipients: an observational study
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753949/
https://www.ncbi.nlm.nih.gov/pubmed/26871853
http://dx.doi.org/10.1097/MD.0000000000002816
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