Cargando…

Sedation with dexmedetomidine in the intensive care setting

Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive. Use of dexmedetomidine as a sedative in the critically ill is associated with fewer opioid requirements compared with propofol and a similar time at goal sedation compared with benzodia...

Descripción completa

Detalles Bibliográficos
Autores principales: Gerlach, Anthony T, Murphy, Claire V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753994/
https://www.ncbi.nlm.nih.gov/pubmed/27147855
http://dx.doi.org/10.2147/OAEM.S17429
_version_ 1782415956578926592
author Gerlach, Anthony T
Murphy, Claire V
author_facet Gerlach, Anthony T
Murphy, Claire V
author_sort Gerlach, Anthony T
collection PubMed
description Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive. Use of dexmedetomidine as a sedative in the critically ill is associated with fewer opioid requirements compared with propofol and a similar time at goal sedation compared with benzodiazepines. Dexmedetomidine may produce negative hemodynamic effects including lower mean heart rates and potentially more bradycardia than other sedatives used in the critically ill. Recent studies have demonstrated that dexmedetomidine is safe at higher dosages, but more studies are needed to determine whether the efficacy of dexmedetomidine is dose dependent. In addition, further research is required to define dexmedetomidine’s role in the care of delirious critically ill patients, as many, but not all, studies have indicated favorable outcomes.
format Online
Article
Text
id pubmed-4753994
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-47539942016-05-04 Sedation with dexmedetomidine in the intensive care setting Gerlach, Anthony T Murphy, Claire V Open Access Emerg Med Review Dexmedetomidine is an α-2 agonist that produces sedation and analgesia without compromising the respiratory drive. Use of dexmedetomidine as a sedative in the critically ill is associated with fewer opioid requirements compared with propofol and a similar time at goal sedation compared with benzodiazepines. Dexmedetomidine may produce negative hemodynamic effects including lower mean heart rates and potentially more bradycardia than other sedatives used in the critically ill. Recent studies have demonstrated that dexmedetomidine is safe at higher dosages, but more studies are needed to determine whether the efficacy of dexmedetomidine is dose dependent. In addition, further research is required to define dexmedetomidine’s role in the care of delirious critically ill patients, as many, but not all, studies have indicated favorable outcomes. Dove Medical Press 2011-11-10 /pmc/articles/PMC4753994/ /pubmed/27147855 http://dx.doi.org/10.2147/OAEM.S17429 Text en © 2011 Gerlach and Murphy, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Gerlach, Anthony T
Murphy, Claire V
Sedation with dexmedetomidine in the intensive care setting
title Sedation with dexmedetomidine in the intensive care setting
title_full Sedation with dexmedetomidine in the intensive care setting
title_fullStr Sedation with dexmedetomidine in the intensive care setting
title_full_unstemmed Sedation with dexmedetomidine in the intensive care setting
title_short Sedation with dexmedetomidine in the intensive care setting
title_sort sedation with dexmedetomidine in the intensive care setting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753994/
https://www.ncbi.nlm.nih.gov/pubmed/27147855
http://dx.doi.org/10.2147/OAEM.S17429
work_keys_str_mv AT gerlachanthonyt sedationwithdexmedetomidineintheintensivecaresetting
AT murphyclairev sedationwithdexmedetomidineintheintensivecaresetting