Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells

Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respec...

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Autores principales: Ma, Xiaojing, Yan, Wenjun, Zheng, Hua, Du, Qinglin, Zhang, Lixing, Ban, Yi, Li, Na, Wei, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754024/
https://www.ncbi.nlm.nih.gov/pubmed/26918147
http://dx.doi.org/10.12688/f1000research.7010.1
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author Ma, Xiaojing
Yan, Wenjun
Zheng, Hua
Du, Qinglin
Zhang, Lixing
Ban, Yi
Li, Na
Wei, Fang
author_facet Ma, Xiaojing
Yan, Wenjun
Zheng, Hua
Du, Qinglin
Zhang, Lixing
Ban, Yi
Li, Na
Wei, Fang
author_sort Ma, Xiaojing
collection PubMed
description Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12.
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spelling pubmed-47540242016-02-24 Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells Ma, Xiaojing Yan, Wenjun Zheng, Hua Du, Qinglin Zhang, Lixing Ban, Yi Li, Na Wei, Fang F1000Res Review Interleukin-10 and Interleukin-12 are produced primarily by pathogen-activated antigen-presenting cells, particularly macrophages and dendritic cells. IL-10 and IL-12 play very important immunoregulatory roles in host defense and immune homeostasis. Being anti- and pro-inflammatory in nature, respectively, their functions are antagonistically opposing. A comprehensive and in-depth understanding of their immunological properties and signaling mechanisms will help develop better clinical intervention strategies in therapy for a wide range of human disorders. Here, we provide an update on some emerging concepts, controversies, unanswered questions, and opinions regarding the immune signaling of IL-10 and IL-12. F1000Research 2015-12-17 /pmc/articles/PMC4754024/ /pubmed/26918147 http://dx.doi.org/10.12688/f1000research.7010.1 Text en Copyright: © 2015 Ma X et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Ma, Xiaojing
Yan, Wenjun
Zheng, Hua
Du, Qinglin
Zhang, Lixing
Ban, Yi
Li, Na
Wei, Fang
Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title_full Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title_fullStr Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title_full_unstemmed Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title_short Regulation of IL-10 and IL-12 production and function in macrophages and dendritic cells
title_sort regulation of il-10 and il-12 production and function in macrophages and dendritic cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754024/
https://www.ncbi.nlm.nih.gov/pubmed/26918147
http://dx.doi.org/10.12688/f1000research.7010.1
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