Cargando…

Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer

Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC an...

Descripción completa

Detalles Bibliográficos
Autores principales: Stacey, Simon N., Kehr, Birte, Gudmundsson, Julius, Zink, Florian, Jonasdottir, Aslaug, Gudjonsson, Sigurjon A., Sigurdsson, Asgeir, Halldorsson, Bjarni V., Agnarsson, Bjarni A., Benediktsdottir, Kristrun R., Aben, Katja K.H., Vermeulen, Sita H., Cremers, Ruben G., Panadero, Angeles, Helfand, Brian T., Cooper, Phillip R., Donovan, Jenny L., Hamdy, Freddie C., Jinga, Viorel, Okamoto, Ichiro, Jonasson, Jon G., Tryggvadottir, Laufey, Johannsdottir, Hrefna, Kristinsdottir, Anna M., Masson, Gisli, Magnusson, Olafur T., Iordache, Paul D., Helgason, Agnar, Helgason, Hannes, Sulem, Patrick, Gudbjartsson, Daniel F., Kong, Augustine, Jonsson, Eirikur, Barkardottir, Rosa B., Einarsson, Gudmundur V., Rafnar, Thorunn, Thorsteinsdottir, Unnur, Mates, Ioan N., Neal, David E., Catalona, William J., Mayordomo, José I., Kiemeney, Lambertus A., Thorleifsson, Gudmar, Stefansson, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754045/
https://www.ncbi.nlm.nih.gov/pubmed/26740556
http://dx.doi.org/10.1093/hmg/ddv622
Descripción
Sumario:Transcriptional and splicing anomalies have been observed in intron 8 of the CASP8 gene (encoding procaspase-8) in association with cutaneous basal-cell carcinoma (BCC) and linked to a germline SNP rs700635. Here, we show that the rs700635[C] allele, which is associated with increased risk of BCC and breast cancer, is protective against prostate cancer [odds ratio (OR) = 0.91, P = 1.0 × 10(−6)]. rs700635[C] is also associated with failures to correctly splice out CASP8 intron 8 in breast and prostate tumours and in corresponding normal tissues. Investigation of rs700635[C] carriers revealed that they have a human-specific short interspersed element-variable number of tandem repeat-Alu (SINE-VNTR-Alu), subfamily-E retrotransposon (SVA-E) inserted into CASP8 intron 8. The SVA-E shows evidence of prior activity, because it has transduced some CASP8 sequences during subsequent retrotransposition events. Whole-genome sequence (WGS) data were used to tag the SVA-E with a surrogate SNP rs1035142[T] (r(2) = 0.999), which showed associations with both the splicing anomalies (P = 6.5 × 10(−32)) and with protection against prostate cancer (OR = 0.91, P = 3.8 × 10(−7)).