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Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack
BACKGROUND: Lacunar infarctions represent 25% of ischemic strokes. Lacunar stroke and transient ischemic attack (TIA) share a number of symptoms. This study aimed to assess the potential risk factors for lacunar infarction in patients with TIA. MATERIAL/METHODS: This was a retrospective study perfor...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754089/ https://www.ncbi.nlm.nih.gov/pubmed/26864634 http://dx.doi.org/10.12659/MSM.895759 |
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author | Li, Ying Liu, Nan Huang, Yonghua Wei, Wei Chen, Fei Zhang, Weiwei |
author_facet | Li, Ying Liu, Nan Huang, Yonghua Wei, Wei Chen, Fei Zhang, Weiwei |
author_sort | Li, Ying |
collection | PubMed |
description | BACKGROUND: Lacunar infarctions represent 25% of ischemic strokes. Lacunar stroke and transient ischemic attack (TIA) share a number of symptoms. This study aimed to assess the potential risk factors for lacunar infarction in patients with TIA. MATERIAL/METHODS: This was a retrospective study performed at the Beijing Military General Hospital in patients with TIA admitted between March 2010 and December 2011. Patients were grouped according to lacunar vs. no lacunar infarction. All patients were diagnosed using diffusion-weighted imaging (DWI) on brain magnetic resonance imaging (MRI). Brain angiography (computed tomography and MRI) was used to measure intracranial stenosis. Carotid artery stenosis was measured by ultrasound. RESULTS: Patients with TIA and lacunar infarction (n=298) were older than those without lacunar infarction (n=157) (69.4±10.0 vs. 58.9±9.0 years, P<0.001) and showed a higher frequency of males (51.7% vs. 41.4%, P=0.037), hypertension (75.3% vs. 45.9%, P<0.001), diabetes (32.6% vs. 21.0%, P=0.010), hyperlipidemia (53.4% vs. 29.3%, P<0.001), carotid stenosis (73.2% vs. 40.1%, P<0.001), and intracranial stenosis (55.6% vs. 31.9%, P<0.001), but a lower frequency of alcohol drinking (8.1% vs. 14.0%, P=0.045). Lacunar infarction mostly involved the anterior circulation (62.8%). Multivariate analysis showed that age (odds ratio (OR)=1.085, 95% confidence interval (95%CI): 1.054–1.117, P<0.001), hypertension (OR=1.738, 95%CI: 1.041–2.903, P=0.035), hyperlipidemia (OR=2.169, 95%CI: 1.307–3.601, P=0.003), and carotid stenosis (OR=1.878, 95%CI: 1.099–3.206, P=0.021) were independently associated with lacunar infarction. CONCLUSIONS: Age, hypertension, hyperlipidemia, and carotid stenosis were independently associated with silent lacunar infarction in patients with TIA. |
format | Online Article Text |
id | pubmed-4754089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-47540892016-02-26 Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack Li, Ying Liu, Nan Huang, Yonghua Wei, Wei Chen, Fei Zhang, Weiwei Med Sci Monit Clinical Research BACKGROUND: Lacunar infarctions represent 25% of ischemic strokes. Lacunar stroke and transient ischemic attack (TIA) share a number of symptoms. This study aimed to assess the potential risk factors for lacunar infarction in patients with TIA. MATERIAL/METHODS: This was a retrospective study performed at the Beijing Military General Hospital in patients with TIA admitted between March 2010 and December 2011. Patients were grouped according to lacunar vs. no lacunar infarction. All patients were diagnosed using diffusion-weighted imaging (DWI) on brain magnetic resonance imaging (MRI). Brain angiography (computed tomography and MRI) was used to measure intracranial stenosis. Carotid artery stenosis was measured by ultrasound. RESULTS: Patients with TIA and lacunar infarction (n=298) were older than those without lacunar infarction (n=157) (69.4±10.0 vs. 58.9±9.0 years, P<0.001) and showed a higher frequency of males (51.7% vs. 41.4%, P=0.037), hypertension (75.3% vs. 45.9%, P<0.001), diabetes (32.6% vs. 21.0%, P=0.010), hyperlipidemia (53.4% vs. 29.3%, P<0.001), carotid stenosis (73.2% vs. 40.1%, P<0.001), and intracranial stenosis (55.6% vs. 31.9%, P<0.001), but a lower frequency of alcohol drinking (8.1% vs. 14.0%, P=0.045). Lacunar infarction mostly involved the anterior circulation (62.8%). Multivariate analysis showed that age (odds ratio (OR)=1.085, 95% confidence interval (95%CI): 1.054–1.117, P<0.001), hypertension (OR=1.738, 95%CI: 1.041–2.903, P=0.035), hyperlipidemia (OR=2.169, 95%CI: 1.307–3.601, P=0.003), and carotid stenosis (OR=1.878, 95%CI: 1.099–3.206, P=0.021) were independently associated with lacunar infarction. CONCLUSIONS: Age, hypertension, hyperlipidemia, and carotid stenosis were independently associated with silent lacunar infarction in patients with TIA. International Scientific Literature, Inc. 2016-02-11 /pmc/articles/PMC4754089/ /pubmed/26864634 http://dx.doi.org/10.12659/MSM.895759 Text en © Med Sci Monit, 2016 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Li, Ying Liu, Nan Huang, Yonghua Wei, Wei Chen, Fei Zhang, Weiwei Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title | Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title_full | Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title_fullStr | Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title_full_unstemmed | Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title_short | Risk Factors for Silent Lacunar Infarction in Patients with Transient Ischemic Attack |
title_sort | risk factors for silent lacunar infarction in patients with transient ischemic attack |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754089/ https://www.ncbi.nlm.nih.gov/pubmed/26864634 http://dx.doi.org/10.12659/MSM.895759 |
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