Cargando…

Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines

BACKGROUND: The nature of the inflammatory response underscoring the pathophysiology of sepsis has been extensively studied. We hypothesized that different cell functions would be differentially regulated in a patient with sepsis. We evaluated the modulation of monocyte functions during sepsis by si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos, Sidnéia S., Carmo, Amanda M., Brunialti, Milena K. C., Machado, Flavia R., Azevedo, Luciano C., Assunção, Murillo, Trevelin, Sílvia C., Cunha, Fernando Q., Salomao, Reinaldo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754229/ https://www.ncbi.nlm.nih.gov/pubmed/26879814 http://dx.doi.org/10.1186/s40635-016-0078-1

Ejemplares similares

Expression of genes belonging to the interacting TLR cascades, NADPH-oxidase and mitochondrial oxidative phosphorylation in septic patients
por: Nucci, Laura A., et al.
Publicado: (2017)

Evaluation of Toll-like, chemokine, and integrin receptors on monocytes and neutrophils from peripheral blood of septic patients and their correlation with clinical outcomes
por: Silva, S.C., et al.
Publicado: (2014)

Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis
por: Martins, Paulo S, et al.
Publicado: (2008)

Downregulation of IL-6 and preserved reactive oxygen species production in human monocytes tolerized by lipopolysaccharide and challenged with Toll-like receptor agonists and whole Gram-negative and Gram-positive bacteria
por: Fernandes, Maria da Luz, et al.
Publicado: (2008)

Increased Percentages of T Helper Cells Producing IL-17 and Monocytes Expressing Markers of Alternative Activation in Patients with Sepsis
por: Colo Brunialti, Milena Karina, et al.
Publicado: (2012)

Coagulation profile in hyperglycemic septic shock patients
por: Sanches, LC, et al.
Publicado: (2010)

Toll-like receptor pathway signaling is differently regulated in neurophils and peripheral mononuclear cells of patients with sepsis, severe sepsis and septic shock
por: Salomão, Reinaldo, et al.
Publicado: (2008)

The Impact of Duration of Organ Dysfunction on the Outcome of Patients with Severe Sepsis and Septic Shock
por: Freitas, Flávio G. R., et al.
Publicado: (2008)

Microparticles from septic shock patients contain microRNA and messenger RNA: new players in the pathogenesis of sepsis?
por: Azevedo, Luciano CP, et al.
Publicado: (2013)

TLR2, TLR4, CD14, CD11b and CD11c expression on monocyte surfaces and cytokine production in septic patients
por: Brunialti, M, et al.
Publicado: (2006)

Lipid metabolism impairment in patients with sepsis secondary to hospital acquired pneumonia, a proteomic analysis
por: Sharma, Narendra Kumar, et al.
Publicado: (2019)

Increased leukocyte oxidative metabolism in severe sepsis and septic shock correlates with organ dysfunction and mortality
por: Martins, P, et al.
Publicado: (2006)

T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality
por: Costa, Ramon Teixeira, et al.
Publicado: (2019)

Proteomic study revealed cellular assembly and lipid metabolism dysregulation in sepsis secondary to community-acquired pneumonia
por: Sharma, Narendra Kumar, et al.
Publicado: (2017)

Evaluation of recognition and signalling receptors on the peripheral blood cells of septic patients and their correlation with clinical outcomes
por: Silva, SC, et al.
Publicado: (2013)

Combined Transcriptome and Proteome Leukocyte’s Profiling Reveals Up-Regulated Module of Genes/Proteins Related to Low Density Neutrophils and Impaired Transcription and Translation Processes in Clinical Sepsis
por: Leite, Giuseppe Gianini Figueirêdo, et al.
Publicado: (2021)

Th17 lymphocytes and alternatively activated monocytes are upregulated in clinical sepsis
por: Salomão, R, et al.
Publicado: (2011)

Decreased phagocytic function in neutrophils and monocytes from peripheral blood in periodontal disease
por: CARNEIRO, Valéria Martins Araújo, et al.
Publicado: (2012)

Increased Serum IL 6 Associated With Mortality and Cognitive Impairment in Elderly Brazilians
por: Caldeira, Marcelo, et al.
Publicado: (2020)

Plasma levels of IL-6 and IL-10 in septic patients at admission and during follow-up and association with clinical outcomes
por: Costa, RT, et al.
Publicado: (2011)

Effects of the PARP Inhibitor Olaparib on the Response of Human Peripheral Blood Leukocytes to Bacterial Challenge or Oxidative Stress
por: Santos, Sidneia Sousa, et al.
Publicado: (2022)

Mechanical Periodontal Therapy Recovered the Phagocytic Function of Monocytes in Periodontitis
por: Naiff, Priscilla F., et al.
Publicado: (2020)

Exosomes from patients with septic shock convey miRNAs related to inflammation and cell cycle regulation: new signaling pathways in sepsis?
por: Real, Juliana Monte, et al.
Publicado: (2018)

Epigenetic Regulation in Sepsis, Role in Pathophysiology and Therapeutic Perspective
por: Falcão-Holanda, Renata Brito, et al.
Publicado: (2021)

Efficacy of Clinically Used PARP Inhibitors in a Murine Model of Acute Lung Injury
por: Martins, Vanessa, et al.
Publicado: (2022)

Transitional B cells and CD21low in patients with ataxia-telangiectasia
por: Bichuetti-Silva, Danielli Christinni, et al.
Publicado: (2015)

Expression of CD40, CD40L and IgM production in patients with ataxia-telangiectasia
por: Pereira, Camila Teles Machado, et al.
Publicado: (2015)

Phagocytic ability of neutrophils and monocytes in neonates
por: Filias, Athanasios, et al.
Publicado: (2011)

Late recognition and illness severity are determinants of early death in severe septic patients
por: Machado, Flavia R., et al.
Publicado: (2013)

Effect of preoperative pregabalin on analgesia and interleukins after lumbotomy: prospective, randomized, comparative, double-blind study
por: Santiago, Ana Ellen Queiroz, et al.
Publicado: (2019)

Phagocytic activity of monocytes and neutrophils in patients with periodontitis, whether or not associated to type 2 diabetes
por: Naiff, Priscilla F, et al.
Publicado: (2021)

Flow Cytometry of Human Primary Epidermal and Follicular Keratinocytes
por: Gragnani, Alfredo, et al.
Publicado: (2008)

Gene expression in peripheral mononuclear cells from septic patients secondary to community-acquired pneumonia: patterns of gene expression and outcomes
por: Severino, P, et al.
Publicado: (2013)

From Flies to Men: ROS and the NADPH Oxidase in Phagocytes
por: Moghadam, Zohreh Mansoori, et al.
Publicado: (2021)

Patterns of Gene Expression in Peripheral Blood Mononuclear Cells and Outcomes from Patients with Sepsis Secondary to Community Acquired Pneumonia
por: Severino, Patricia, et al.
Publicado: (2014)

Gene expression profiling of mononuclear cells from patients with sepsis secondary to community-acquired pneumonia
por: Severino, Patricia, et al.
Publicado: (2014)

Sepsis: evolving concepts and challenges
por: Salomão, R., et al.
Publicado: (2019)

C(60) fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes
por: Skivka, Larysa M., et al.
Publicado: (2018)

Monocyte phagocytic function in patients with breast cancer during therapy
por: Baskic, D, et al.
Publicado: (2001)

Proteomic characterization of phagocytic primary human monocyte-derived macrophages
por: Volk, Regan F., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4r0542qrb2hi9te5intbs43ara