Cargando…

Biotechnological production of hyaluronic acid: a mini review

Hyaluronic acid (HA) is a polysaccharide found in the extracellular matrix of vertebrate epithelial, neural and connective tissues. Due to the high moisture retention, biocompatibility and viscoelasticity properties of this polymer, HA has become an important component of major pharmaceutical, biome...

Descripción completa

Detalles Bibliográficos
Autores principales: Sze, Jun Hui, Brownlie, Jeremy C., Love, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754297/
https://www.ncbi.nlm.nih.gov/pubmed/28330137
http://dx.doi.org/10.1007/s13205-016-0379-9
_version_ 1782415990748872704
author Sze, Jun Hui
Brownlie, Jeremy C.
Love, Christopher A.
author_facet Sze, Jun Hui
Brownlie, Jeremy C.
Love, Christopher A.
author_sort Sze, Jun Hui
collection PubMed
description Hyaluronic acid (HA) is a polysaccharide found in the extracellular matrix of vertebrate epithelial, neural and connective tissues. Due to the high moisture retention, biocompatibility and viscoelasticity properties of this polymer, HA has become an important component of major pharmaceutical, biomedical and cosmetic products with high commercial value worldwide. Currently, large scale production of HA involves extraction from animal tissues as well as the use of bacterial expression systems in Streptococci. However, due to concerns over safety, alternative sources of HA have been pursued which include the use of endotoxin-free microorganisms such as Bacilli and Escherichia coli. In this review, we explore current knowledge of biosynthetic enzymes that produce HA, how these systems have been used commercially to produce HA and how the challenges of producing HA cheaply and safely are being addressed.
format Online
Article
Text
id pubmed-4754297
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-47542972016-02-16 Biotechnological production of hyaluronic acid: a mini review Sze, Jun Hui Brownlie, Jeremy C. Love, Christopher A. 3 Biotech Review Article Hyaluronic acid (HA) is a polysaccharide found in the extracellular matrix of vertebrate epithelial, neural and connective tissues. Due to the high moisture retention, biocompatibility and viscoelasticity properties of this polymer, HA has become an important component of major pharmaceutical, biomedical and cosmetic products with high commercial value worldwide. Currently, large scale production of HA involves extraction from animal tissues as well as the use of bacterial expression systems in Streptococci. However, due to concerns over safety, alternative sources of HA have been pursued which include the use of endotoxin-free microorganisms such as Bacilli and Escherichia coli. In this review, we explore current knowledge of biosynthetic enzymes that produce HA, how these systems have been used commercially to produce HA and how the challenges of producing HA cheaply and safely are being addressed. Springer Berlin Heidelberg 2016-02-15 2016-06 /pmc/articles/PMC4754297/ /pubmed/28330137 http://dx.doi.org/10.1007/s13205-016-0379-9 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review Article
Sze, Jun Hui
Brownlie, Jeremy C.
Love, Christopher A.
Biotechnological production of hyaluronic acid: a mini review
title Biotechnological production of hyaluronic acid: a mini review
title_full Biotechnological production of hyaluronic acid: a mini review
title_fullStr Biotechnological production of hyaluronic acid: a mini review
title_full_unstemmed Biotechnological production of hyaluronic acid: a mini review
title_short Biotechnological production of hyaluronic acid: a mini review
title_sort biotechnological production of hyaluronic acid: a mini review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754297/
https://www.ncbi.nlm.nih.gov/pubmed/28330137
http://dx.doi.org/10.1007/s13205-016-0379-9
work_keys_str_mv AT szejunhui biotechnologicalproductionofhyaluronicacidaminireview
AT brownliejeremyc biotechnologicalproductionofhyaluronicacidaminireview
AT lovechristophera biotechnologicalproductionofhyaluronicacidaminireview