Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice

Enzyme replacement therapy (ERT) is an effective treatment for several lysosomal storage disorders (LSDs). Intravenously infused enzymes are taken up by tissues through either the mannose 6-phosphate receptor (M6PR) or the mannose receptor (MR). It is generally believed that M6PR-mediated endocytosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Jin-Song, Busch, Andreas, Day, Taniqua S., Meng, Xing-Li, Yu, Chun I., Dabrowska-Schlepp, Paulina, Fode, Benjamin, Niederkrüger, Holger, Forni, Sabrina, Chen, Shuyuan, Schiffmann, Raphael, Frischmuth, Thomas, Schaaf, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754329/
https://www.ncbi.nlm.nih.gov/pubmed/26310963
http://dx.doi.org/10.1007/s10545-015-9886-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754329/
https://www.ncbi.nlm.nih.gov/pubmed/26310963
http://dx.doi.org/10.1007/s10545-015-9886-9

Ejemplares similares