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Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are curr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754338/ https://www.ncbi.nlm.nih.gov/pubmed/26869263 http://dx.doi.org/10.1038/ncomms10702 |
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author | Berrios, Janet Stamatakis, Alice M. Kantak, Pranish A. McElligott, Zoe A. Judson, Matthew C. Aita, Megumi Rougie, Marie Stuber, Garret D. Philpot, Benjamin D. |
author_facet | Berrios, Janet Stamatakis, Alice M. Kantak, Pranish A. McElligott, Zoe A. Judson, Matthew C. Aita, Megumi Rougie, Marie Stuber, Garret D. Philpot, Benjamin D. |
author_sort | Berrios, Janet |
collection | PubMed |
description | Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation. |
format | Online Article Text |
id | pubmed-4754338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47543382016-03-04 Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation Berrios, Janet Stamatakis, Alice M. Kantak, Pranish A. McElligott, Zoe A. Judson, Matthew C. Aita, Megumi Rougie, Marie Stuber, Garret D. Philpot, Benjamin D. Nat Commun Article Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation. Nature Publishing Group 2016-02-12 /pmc/articles/PMC4754338/ /pubmed/26869263 http://dx.doi.org/10.1038/ncomms10702 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Berrios, Janet Stamatakis, Alice M. Kantak, Pranish A. McElligott, Zoe A. Judson, Matthew C. Aita, Megumi Rougie, Marie Stuber, Garret D. Philpot, Benjamin D. Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title | Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title_full | Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title_fullStr | Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title_full_unstemmed | Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title_short | Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation |
title_sort | loss of ube3a from th-expressing neurons suppresses gaba co-release and enhances vta-nac optical self-stimulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754338/ https://www.ncbi.nlm.nih.gov/pubmed/26869263 http://dx.doi.org/10.1038/ncomms10702 |
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