Cargando…

Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are curr...

Descripción completa

Detalles Bibliográficos
Autores principales: Berrios, Janet, Stamatakis, Alice M., Kantak, Pranish A., McElligott, Zoe A., Judson, Matthew C., Aita, Megumi, Rougie, Marie, Stuber, Garret D., Philpot, Benjamin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754338/
https://www.ncbi.nlm.nih.gov/pubmed/26869263
http://dx.doi.org/10.1038/ncomms10702
_version_ 1782415996190982144
author Berrios, Janet
Stamatakis, Alice M.
Kantak, Pranish A.
McElligott, Zoe A.
Judson, Matthew C.
Aita, Megumi
Rougie, Marie
Stuber, Garret D.
Philpot, Benjamin D.
author_facet Berrios, Janet
Stamatakis, Alice M.
Kantak, Pranish A.
McElligott, Zoe A.
Judson, Matthew C.
Aita, Megumi
Rougie, Marie
Stuber, Garret D.
Philpot, Benjamin D.
author_sort Berrios, Janet
collection PubMed
description Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation.
format Online
Article
Text
id pubmed-4754338
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-47543382016-03-04 Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation Berrios, Janet Stamatakis, Alice M. Kantak, Pranish A. McElligott, Zoe A. Judson, Matthew C. Aita, Megumi Rougie, Marie Stuber, Garret D. Philpot, Benjamin D. Nat Commun Article Motivated reward-seeking behaviours are governed by dopaminergic ventral tegmental area projections to the nucleus accumbens. In addition to dopamine, these mesoaccumbal terminals co-release other neurotransmitters including glutamate and GABA, whose roles in regulating motivated behaviours are currently being investigated. Here we demonstrate that loss of the E3-ubiquitin ligase, UBE3A, from tyrosine hydroxylase-expressing neurons impairs mesoaccumbal, non-canonical GABA co-release and enhances reward-seeking behaviour measured by optical self-stimulation. Nature Publishing Group 2016-02-12 /pmc/articles/PMC4754338/ /pubmed/26869263 http://dx.doi.org/10.1038/ncomms10702 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Berrios, Janet
Stamatakis, Alice M.
Kantak, Pranish A.
McElligott, Zoe A.
Judson, Matthew C.
Aita, Megumi
Rougie, Marie
Stuber, Garret D.
Philpot, Benjamin D.
Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_full Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_fullStr Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_full_unstemmed Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_short Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation
title_sort loss of ube3a from th-expressing neurons suppresses gaba co-release and enhances vta-nac optical self-stimulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754338/
https://www.ncbi.nlm.nih.gov/pubmed/26869263
http://dx.doi.org/10.1038/ncomms10702
work_keys_str_mv AT berriosjanet lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT stamatakisalicem lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT kantakpranisha lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT mcelligottzoea lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT judsonmatthewc lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT aitamegumi lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT rougiemarie lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT stubergarretd lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation
AT philpotbenjamind lossofube3afromthexpressingneuronssuppressesgabacoreleaseandenhancesvtanacopticalselfstimulation