A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology

Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and replicate a locus indexed by rs77728904 at 9p21.3 assoc...

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Detalles Bibliográficos
Autores principales: Hungate, Eric A., Vora, Sapana R., Gamazon, Eric R., Moriyama, Takaya, Best, Timothy, Hulur, Imge, Lee, Younghee, Evans, Tiffany-Jane, Ellinghaus, Eva, Stanulla, Martin, Rudant, Jéremie, Orsi, Laurent, Clavel, Jacqueline, Milne, Elizabeth, Scott, Rodney J., Pui, Ching-Hon, Cox, Nancy J., Loh, Mignon L., Yang, Jun J., Skol, Andrew D., Onel, Kenan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754340/
https://www.ncbi.nlm.nih.gov/pubmed/26868379
http://dx.doi.org/10.1038/ncomms10635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754340/
https://www.ncbi.nlm.nih.gov/pubmed/26868379
http://dx.doi.org/10.1038/ncomms10635

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