SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing

SIRT7 is an NAD(+)-dependent protein deacetylase with important roles in ribosome biogenesis and cell proliferation. Previous studies have established that SIRT7 is associated with RNA polymerase I, interacts with pre-ribosomal RNA (rRNA) and promotes rRNA synthesis. Here we show that SIRT7 is also...

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Detalles Bibliográficos
Autores principales: Chen, Sifan, Blank, Maximilian Felix, Iyer, Aishwarya, Huang, Bingding, Wang, Lin, Grummt, Ingrid, Voit, Renate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754350/
https://www.ncbi.nlm.nih.gov/pubmed/26867678
http://dx.doi.org/10.1038/ncomms10734

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