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The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation

INTRODUCTION: The efficacy of pulmonary vein isolation (PVI) in atrial fibrillation (AF) is well documented. Several single nucleotide polymorphisms (SNPs) are associated with AF, mainly in the 4q25 locus, but also in 16q22 and 1q21. The aim of our study was to test the association between those SNP...

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Autores principales: Kiliszek, Marek, Kozluk, Edward, Franaszczyk, Maria, Lodzinski, Piotr, Piatkowska, Agnieszka, Ploski, Rafal, Opolski, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754358/
https://www.ncbi.nlm.nih.gov/pubmed/26925117
http://dx.doi.org/10.5114/aoms.2015.48284
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author Kiliszek, Marek
Kozluk, Edward
Franaszczyk, Maria
Lodzinski, Piotr
Piatkowska, Agnieszka
Ploski, Rafal
Opolski, Grzegorz
author_facet Kiliszek, Marek
Kozluk, Edward
Franaszczyk, Maria
Lodzinski, Piotr
Piatkowska, Agnieszka
Ploski, Rafal
Opolski, Grzegorz
author_sort Kiliszek, Marek
collection PubMed
description INTRODUCTION: The efficacy of pulmonary vein isolation (PVI) in atrial fibrillation (AF) is well documented. Several single nucleotide polymorphisms (SNPs) are associated with AF, mainly in the 4q25 locus, but also in 16q22 and 1q21. The aim of our study was to test the association between those SNPs and short- and long-term results of PVI. MATERIAL AND METHODS: Patients with AF who underwent PVI between 2006 and 2009 were included in the study. Pulmonary vein isolation was performed using a 4-mm non-irrigated ablation catheter, circular mapping catheter, and the LocaLisa system. All patients were genotyped for the 4q25, 16q22, and 1q21 SNPs. RESULTS: Two-hundred and thirty-eight patients were included. The median follow-up was 45 months. Six-month efficacy was 59.7%. None of the polymorphisms was linked with the risk of AF recurrence after 6 months in univariate analysis. In multivariate analysis rs2200733 in the recessive model was linked significantly with AF recurrence (odds ratio 1.87, p = 0.008). None of the polymorphisms predicted AF recurrence in long-term follow-up. CONCLUSIONS: There is a trend in the relationship between TT genotype of the rs2200733 polymorphism and increased rate of AF recurrence after PVI in short-term (6 months) follow-up. None of the tested SNPs 4q25, 16q22, and 1q21 correlated with the results of a single AF ablation in long-term follow-up.
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spelling pubmed-47543582016-02-26 The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation Kiliszek, Marek Kozluk, Edward Franaszczyk, Maria Lodzinski, Piotr Piatkowska, Agnieszka Ploski, Rafal Opolski, Grzegorz Arch Med Sci Clinical Research INTRODUCTION: The efficacy of pulmonary vein isolation (PVI) in atrial fibrillation (AF) is well documented. Several single nucleotide polymorphisms (SNPs) are associated with AF, mainly in the 4q25 locus, but also in 16q22 and 1q21. The aim of our study was to test the association between those SNPs and short- and long-term results of PVI. MATERIAL AND METHODS: Patients with AF who underwent PVI between 2006 and 2009 were included in the study. Pulmonary vein isolation was performed using a 4-mm non-irrigated ablation catheter, circular mapping catheter, and the LocaLisa system. All patients were genotyped for the 4q25, 16q22, and 1q21 SNPs. RESULTS: Two-hundred and thirty-eight patients were included. The median follow-up was 45 months. Six-month efficacy was 59.7%. None of the polymorphisms was linked with the risk of AF recurrence after 6 months in univariate analysis. In multivariate analysis rs2200733 in the recessive model was linked significantly with AF recurrence (odds ratio 1.87, p = 0.008). None of the polymorphisms predicted AF recurrence in long-term follow-up. CONCLUSIONS: There is a trend in the relationship between TT genotype of the rs2200733 polymorphism and increased rate of AF recurrence after PVI in short-term (6 months) follow-up. None of the tested SNPs 4q25, 16q22, and 1q21 correlated with the results of a single AF ablation in long-term follow-up. Termedia Publishing House 2016-02-02 2016-02-01 /pmc/articles/PMC4754358/ /pubmed/26925117 http://dx.doi.org/10.5114/aoms.2015.48284 Text en Copyright © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Kiliszek, Marek
Kozluk, Edward
Franaszczyk, Maria
Lodzinski, Piotr
Piatkowska, Agnieszka
Ploski, Rafal
Opolski, Grzegorz
The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title_full The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title_fullStr The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title_full_unstemmed The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title_short The 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
title_sort 4q25, 1q21, and 16q22 polymorphisms and recurrence of atrial fibrillation after pulmonary vein isolation
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754358/
https://www.ncbi.nlm.nih.gov/pubmed/26925117
http://dx.doi.org/10.5114/aoms.2015.48284
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