An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy

Candida species can cause severe infections associated with high morbidity and mortality. Therefore, it is essential to gain more insight into the anti-fungal host defense response. The advent of omics technology and development of advanced systems biology tools has permitted to approach this in an...

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Autores principales: Smeekens, S. P., van de Veerdonk, F. L., Netea, M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754423/
https://www.ncbi.nlm.nih.gov/pubmed/26909070
http://dx.doi.org/10.3389/fmicb.2016.00154
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author Smeekens, S. P.
van de Veerdonk, F. L.
Netea, M. G.
author_facet Smeekens, S. P.
van de Veerdonk, F. L.
Netea, M. G.
author_sort Smeekens, S. P.
collection PubMed
description Candida species can cause severe infections associated with high morbidity and mortality. Therefore, it is essential to gain more insight into the anti-fungal host defense response. The advent of omics technology and development of advanced systems biology tools has permitted to approach this in an unbiased and quantitative manner. This review summarizes the insights gained on anti-Candida immunity from genetic-, transcriptome-, proteome-, metabolome-, microbiome-, mycobiome-, and computational systems biology studies and discusses practical aspects and future perspectives.
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spelling pubmed-47544232016-02-23 An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy Smeekens, S. P. van de Veerdonk, F. L. Netea, M. G. Front Microbiol Microbiology Candida species can cause severe infections associated with high morbidity and mortality. Therefore, it is essential to gain more insight into the anti-fungal host defense response. The advent of omics technology and development of advanced systems biology tools has permitted to approach this in an unbiased and quantitative manner. This review summarizes the insights gained on anti-Candida immunity from genetic-, transcriptome-, proteome-, metabolome-, microbiome-, mycobiome-, and computational systems biology studies and discusses practical aspects and future perspectives. Frontiers Media S.A. 2016-02-16 /pmc/articles/PMC4754423/ /pubmed/26909070 http://dx.doi.org/10.3389/fmicb.2016.00154 Text en Copyright © 2016 Smeekens, van de Veerdonk and Netea. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Smeekens, S. P.
van de Veerdonk, F. L.
Netea, M. G.
An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title_full An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title_fullStr An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title_full_unstemmed An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title_short An Omics Perspective on Candida Infections: Toward Next-Generation Diagnosis and Therapy
title_sort omics perspective on candida infections: toward next-generation diagnosis and therapy
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754423/
https://www.ncbi.nlm.nih.gov/pubmed/26909070
http://dx.doi.org/10.3389/fmicb.2016.00154
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