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IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity

IGHV polymorphism provides a rich source of humoral immune system diversity. One important example is the IGHV1-69 germline gene where the biased use of alleles that encode the critical CDR-H2 Phe54 (F-alleles) to make broadly neutralizing antibodies (HV1-69-sBnAb) to the influenza A hemagglutinin s...

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Detalles Bibliográficos
Autores principales:	Avnir, Yuval, Watson, Corey T., Glanville, Jacob, Peterson, Eric C., Tallarico, Aimee S., Bennett, Andrew S., Qin, Kun, Fu, Ying, Huang, Chiung-Yu, Beigel, John H., Breden, Felix, Zhu, Quan, Marasco, Wayne A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754645/ https://www.ncbi.nlm.nih.gov/pubmed/26880249 http://dx.doi.org/10.1038/srep20842

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