Conformational Flexibility of a Short Loop near the Active Site of the SARS-3CLpro is Essential to Maintain Catalytic Activity

The SARS 3C-like proteinase (SARS-3CLpro), which is the main proteinase of the SARS coronavirus, is essential to the virus life cycle. This enzyme has been shown to be active as a dimer in which only one protomer is active. However, it remains unknown how the dimer structure maintains an active mono...

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Detalles Bibliográficos
Autores principales: Li, Chunmei, Teng, Xin, Qi, Yifei, Tang, Bo, Shi, Hailing, Ma, Xiaomin, Lai, Luhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754693/
https://www.ncbi.nlm.nih.gov/pubmed/26879383
http://dx.doi.org/10.1038/srep20918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754693/
https://www.ncbi.nlm.nih.gov/pubmed/26879383
http://dx.doi.org/10.1038/srep20918

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