Cargando…
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
Members of the desmosome protein family are integral components of the cardiac area composita, a mixed junctional complex responsible for electromechanical coupling between cardiomyocytes. In this study, we provide evidence that loss of the desmosomal armadillo protein Plakophilin-2 (PKP2) in cardio...
Autores principales: | Dubash, Adi D., Kam, Chen Y., Aguado, Brian A., Patel, Dipal M., Delmar, Mario, Shea, Lonnie D., Green, Kathleen J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754716/ https://www.ncbi.nlm.nih.gov/pubmed/26858265 http://dx.doi.org/10.1083/jcb.201507018 |
Ejemplares similares
-
Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes
por: Dubash, Adi D., et al.
Publicado: (2016) -
Plakophilin 2 Couples Actomyosin Remodeling to Desmosomal Plaque Assembly via RhoA
por: Godsel, Lisa M., et al.
Publicado: (2010) -
Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin–EB1 interactions
por: Patel, Dipal M., et al.
Publicado: (2014) -
Defining desmosomal plakophilin-3 interactions
por: Bonné, Stefan, et al.
Publicado: (2003) -
Blockade of the Adenosine 2A Receptor Mitigates the Cardiomyopathy Induced by Loss of Plakophilin-2 Expression
por: Cerrone, Marina, et al.
Publicado: (2018)