Plakophilin-2 loss promotes TGF-β1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes

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Members of the desmosome protein family are integral components of the cardiac area composita, a mixed junctional complex responsible for electromechanical coupling between cardiomyocytes. In this study, we provide evidence that loss of the desmosomal armadillo protein Plakophilin-2 (PKP2) in cardio...

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Detalles Bibliográficos
Autores principales: Dubash, Adi D., Kam, Chen Y., Aguado, Brian A., Patel, Dipal M., Delmar, Mario, Shea, Lonnie D., Green, Kathleen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754716/
https://www.ncbi.nlm.nih.gov/pubmed/26858265
http://dx.doi.org/10.1083/jcb.201507018
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