A single residue substitution accounts for the significant difference in thermostability between two isoforms of human cytosolic creatine kinase

Creatine kinase (CK) helps maintain homeostasis of intracellular ATP level by catalyzing the reversible phosphotransfer between ATP and phosphocreatine. In humans, there are two cytosolic CK isoforms, the muscle-type (M) and the brain-type (B), which frequently function as homodimers (hMMCK and hBBC...

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Detalles Bibliográficos
Autores principales: Liu, Huihui, Gao, Yan-Song, Chen, Xiang-Jun, Chen, Zhe, Zhou, Hai-Meng, Yan, Yong-Bin, Gong, Haipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754747/
https://www.ncbi.nlm.nih.gov/pubmed/26879258
http://dx.doi.org/10.1038/srep21191

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