Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity

Manganese (Mn(2+)) neurotoxicity from occupational exposure is well documented to result in a Parkinson-like syndrome. Although the understanding of Mn(2+) cytotoxicity is still incomplete, both Mn(2+) and Fe(2+) can be transported via the divalent metal transporter 1 (DMT1), suggesting that competi...

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Detalles Bibliográficos
Autores principales: Tai, Yee Kit, Chew, Katherine C. M., Tan, Bryce W. Q., Lim, Kah-Leong, Soong, Tuck Wah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754755/
https://www.ncbi.nlm.nih.gov/pubmed/26878799
http://dx.doi.org/10.1038/srep21113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754755/
https://www.ncbi.nlm.nih.gov/pubmed/26878799
http://dx.doi.org/10.1038/srep21113

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