Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions

Cancer was hypothesized to be driven by cancer stem cells (CSCs), but the metabolic determinants of CSC-like phenotype still remain elusive. Here, we present that hexosamine biosynthetic pathway (HBP) at least in part rescues cancer cell fate with inactivation of glycolysis. Firstly, metabolomic ana...

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Detalles Bibliográficos
Autores principales: Lin, Shu-Hai, Liu, Tengfei, Ming, Xiaoyan, Tang, Zhi, Fu, Li, Schmitt-Kopplin, Philippe, Kanawati, Basem, Guan, Xin-Yuan, Cai, Zongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754761/
https://www.ncbi.nlm.nih.gov/pubmed/26878908
http://dx.doi.org/10.1038/srep21184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754761/
https://www.ncbi.nlm.nih.gov/pubmed/26878908
http://dx.doi.org/10.1038/srep21184

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