Cargando…
Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigat...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754797/ https://www.ncbi.nlm.nih.gov/pubmed/26880358 http://dx.doi.org/10.1038/srep21227 |
_version_ | 1782416084965523456 |
---|---|
author | Misaki, Masaya Suzuki, Hideo Savitz, Jonathan Drevets, Wayne C. Bodurka, Jerzy |
author_facet | Misaki, Masaya Suzuki, Hideo Savitz, Jonathan Drevets, Wayne C. Bodurka, Jerzy |
author_sort | Misaki, Masaya |
collection | PubMed |
description | Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigated variation of NAcc responses to gain and loss anticipations using fMRI. We found NAcc responses to monetary gain and loss were significantly variable across subjects in both MDD and healthy control (HC) groups. The variations were seen as a hyperactive response subtype that showed elevated activation to the anticipation of both gain and loss, an intermediate response with greater activation to gain than loss, and a suppressed-activity with reduced activation to both gain and loss compared to a non-monetary condition. While these response variability were seen in both MDD and HC subjects, specific symptoms were significantly associated with the right NAcc variation in MDD. Both the hyper- and suppressed-activity subtypes of MDD patients had severe suicidal ideation and anhedonia symptoms. The intermediate subjects had less severity in these symptoms. These results suggest that differing propensities in reward responsiveness in the NAcc may affect the development of specific symptoms in MDD. |
format | Online Article Text |
id | pubmed-4754797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47547972016-02-24 Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms Misaki, Masaya Suzuki, Hideo Savitz, Jonathan Drevets, Wayne C. Bodurka, Jerzy Sci Rep Article Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigated variation of NAcc responses to gain and loss anticipations using fMRI. We found NAcc responses to monetary gain and loss were significantly variable across subjects in both MDD and healthy control (HC) groups. The variations were seen as a hyperactive response subtype that showed elevated activation to the anticipation of both gain and loss, an intermediate response with greater activation to gain than loss, and a suppressed-activity with reduced activation to both gain and loss compared to a non-monetary condition. While these response variability were seen in both MDD and HC subjects, specific symptoms were significantly associated with the right NAcc variation in MDD. Both the hyper- and suppressed-activity subtypes of MDD patients had severe suicidal ideation and anhedonia symptoms. The intermediate subjects had less severity in these symptoms. These results suggest that differing propensities in reward responsiveness in the NAcc may affect the development of specific symptoms in MDD. Nature Publishing Group 2016-02-16 /pmc/articles/PMC4754797/ /pubmed/26880358 http://dx.doi.org/10.1038/srep21227 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Misaki, Masaya Suzuki, Hideo Savitz, Jonathan Drevets, Wayne C. Bodurka, Jerzy Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title | Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title_full | Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title_fullStr | Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title_full_unstemmed | Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title_short | Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms |
title_sort | individual variations in nucleus accumbens responses associated with major depressive disorder symptoms |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754797/ https://www.ncbi.nlm.nih.gov/pubmed/26880358 http://dx.doi.org/10.1038/srep21227 |
work_keys_str_mv | AT misakimasaya individualvariationsinnucleusaccumbensresponsesassociatedwithmajordepressivedisordersymptoms AT suzukihideo individualvariationsinnucleusaccumbensresponsesassociatedwithmajordepressivedisordersymptoms AT savitzjonathan individualvariationsinnucleusaccumbensresponsesassociatedwithmajordepressivedisordersymptoms AT drevetswaynec individualvariationsinnucleusaccumbensresponsesassociatedwithmajordepressivedisordersymptoms AT bodurkajerzy individualvariationsinnucleusaccumbensresponsesassociatedwithmajordepressivedisordersymptoms |