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Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms

Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigat...

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Autores principales: Misaki, Masaya, Suzuki, Hideo, Savitz, Jonathan, Drevets, Wayne C., Bodurka, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754797/
https://www.ncbi.nlm.nih.gov/pubmed/26880358
http://dx.doi.org/10.1038/srep21227
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author Misaki, Masaya
Suzuki, Hideo
Savitz, Jonathan
Drevets, Wayne C.
Bodurka, Jerzy
author_facet Misaki, Masaya
Suzuki, Hideo
Savitz, Jonathan
Drevets, Wayne C.
Bodurka, Jerzy
author_sort Misaki, Masaya
collection PubMed
description Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigated variation of NAcc responses to gain and loss anticipations using fMRI. We found NAcc responses to monetary gain and loss were significantly variable across subjects in both MDD and healthy control (HC) groups. The variations were seen as a hyperactive response subtype that showed elevated activation to the anticipation of both gain and loss, an intermediate response with greater activation to gain than loss, and a suppressed-activity with reduced activation to both gain and loss compared to a non-monetary condition. While these response variability were seen in both MDD and HC subjects, specific symptoms were significantly associated with the right NAcc variation in MDD. Both the hyper- and suppressed-activity subtypes of MDD patients had severe suicidal ideation and anhedonia symptoms. The intermediate subjects had less severity in these symptoms. These results suggest that differing propensities in reward responsiveness in the NAcc may affect the development of specific symptoms in MDD.
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spelling pubmed-47547972016-02-24 Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms Misaki, Masaya Suzuki, Hideo Savitz, Jonathan Drevets, Wayne C. Bodurka, Jerzy Sci Rep Article Abnormal reward-related responses in the nucleus accumbens (NAcc) have been reported for major depressive disorder (MDD) patients. However, variability exists in the reported results, which could be due to heterogeneity in neuropathology of depression. To parse the heterogeneity of MDD we investigated variation of NAcc responses to gain and loss anticipations using fMRI. We found NAcc responses to monetary gain and loss were significantly variable across subjects in both MDD and healthy control (HC) groups. The variations were seen as a hyperactive response subtype that showed elevated activation to the anticipation of both gain and loss, an intermediate response with greater activation to gain than loss, and a suppressed-activity with reduced activation to both gain and loss compared to a non-monetary condition. While these response variability were seen in both MDD and HC subjects, specific symptoms were significantly associated with the right NAcc variation in MDD. Both the hyper- and suppressed-activity subtypes of MDD patients had severe suicidal ideation and anhedonia symptoms. The intermediate subjects had less severity in these symptoms. These results suggest that differing propensities in reward responsiveness in the NAcc may affect the development of specific symptoms in MDD. Nature Publishing Group 2016-02-16 /pmc/articles/PMC4754797/ /pubmed/26880358 http://dx.doi.org/10.1038/srep21227 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Misaki, Masaya
Suzuki, Hideo
Savitz, Jonathan
Drevets, Wayne C.
Bodurka, Jerzy
Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title_full Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title_fullStr Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title_full_unstemmed Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title_short Individual Variations in Nucleus Accumbens Responses Associated with Major Depressive Disorder Symptoms
title_sort individual variations in nucleus accumbens responses associated with major depressive disorder symptoms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754797/
https://www.ncbi.nlm.nih.gov/pubmed/26880358
http://dx.doi.org/10.1038/srep21227
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