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The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people

BACKGROUND: To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and centenarians. METHODS: Subjects were from the Project of Longevity and Aging in Dujiangyan (PLAD). The genotyping of G-395A (rs1207568)...

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Autores principales: Luo, Li, Hao, Qiukui, Dong, Birong, Yang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754834/
https://www.ncbi.nlm.nih.gov/pubmed/26880028
http://dx.doi.org/10.1186/s12877-016-0221-6
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author Luo, Li
Hao, Qiukui
Dong, Birong
Yang, Ming
author_facet Luo, Li
Hao, Qiukui
Dong, Birong
Yang, Ming
author_sort Luo, Li
collection PubMed
description BACKGROUND: To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and centenarians. METHODS: Subjects were from the Project of Longevity and Aging in Dujiangyan (PLAD). The genotyping of G-395A (rs1207568) in the promoter region of the Klotho gene was performed using the TaqMan allelic discrimination assay. MetS was diagnosed according to the International Diabetes Federation criteria. RESULTS: We included 695 subjects aged 93.5 ± 3.2 years. G and A allele frequencies were 0.852 and 0.148, respectively. In the whole population, the frequency of MetS was 10.8 % and 5.9 % in the GG and GA + AA genotype group, respectively (p = 0.004). The -395A allele carriers had significantly lower risk of MetS in the whole population (odd ratio [OR] 0.50, 95 % confidential interval [CI] 0.25 to 0.98) and in women (OR 0.51, 95 % CI 0.24 to 0.97), but not in men (OR 0.42, 95 % CI 0.05 to 3.85). In the whole population and women, the relationship between the Klotho G-395A SNP and MetS might due to its influence on high blood pressure (OR 0.48, 95 % CI 0.34 to 0.67; OR 0.47, 95 % CI 0.31 to 0.71, respectively) and hypertriglyceridemia (OR 0.66, 95 % CI 0.39 to 0.95; OR 0.54, 95 % CI 0.31 to 0.98, respectively). In men, this relationship might due to its influence on high blood pressure (OR 0.47, 95 % CI 0.25 to 0.90) and low HDL-C (OR 0.69, 95 % CI 0.27 to 0.93). CONCLUSIONS: The -395A allele carriers of the Klotho gene were correlated with lower risk of MetS among Chinese nonagenarians and centenarians, especially in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12877-016-0221-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-47548342016-02-17 The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people Luo, Li Hao, Qiukui Dong, Birong Yang, Ming BMC Geriatr Research Article BACKGROUND: To investigate the possible association of the Klotho G-395A polymorphism and metabolic syndrome (MetS) among a population of Chinese nonagenarians and centenarians. METHODS: Subjects were from the Project of Longevity and Aging in Dujiangyan (PLAD). The genotyping of G-395A (rs1207568) in the promoter region of the Klotho gene was performed using the TaqMan allelic discrimination assay. MetS was diagnosed according to the International Diabetes Federation criteria. RESULTS: We included 695 subjects aged 93.5 ± 3.2 years. G and A allele frequencies were 0.852 and 0.148, respectively. In the whole population, the frequency of MetS was 10.8 % and 5.9 % in the GG and GA + AA genotype group, respectively (p = 0.004). The -395A allele carriers had significantly lower risk of MetS in the whole population (odd ratio [OR] 0.50, 95 % confidential interval [CI] 0.25 to 0.98) and in women (OR 0.51, 95 % CI 0.24 to 0.97), but not in men (OR 0.42, 95 % CI 0.05 to 3.85). In the whole population and women, the relationship between the Klotho G-395A SNP and MetS might due to its influence on high blood pressure (OR 0.48, 95 % CI 0.34 to 0.67; OR 0.47, 95 % CI 0.31 to 0.71, respectively) and hypertriglyceridemia (OR 0.66, 95 % CI 0.39 to 0.95; OR 0.54, 95 % CI 0.31 to 0.98, respectively). In men, this relationship might due to its influence on high blood pressure (OR 0.47, 95 % CI 0.25 to 0.90) and low HDL-C (OR 0.69, 95 % CI 0.27 to 0.93). CONCLUSIONS: The -395A allele carriers of the Klotho gene were correlated with lower risk of MetS among Chinese nonagenarians and centenarians, especially in women. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12877-016-0221-6) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-15 /pmc/articles/PMC4754834/ /pubmed/26880028 http://dx.doi.org/10.1186/s12877-016-0221-6 Text en © Luo et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Luo, Li
Hao, Qiukui
Dong, Birong
Yang, Ming
The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title_full The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title_fullStr The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title_full_unstemmed The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title_short The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
title_sort klotho gene g-395a polymorphism and metabolic syndrome in very elderly people
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754834/
https://www.ncbi.nlm.nih.gov/pubmed/26880028
http://dx.doi.org/10.1186/s12877-016-0221-6
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