Cargando…
A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women
BACKGROUND: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and e...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754934/ https://www.ncbi.nlm.nih.gov/pubmed/26880234 http://dx.doi.org/10.1186/s12889-016-2824-4 |
_version_ | 1782416115358498816 |
---|---|
author | Kile, Molly L. Faraj, Joycelyn M. Ronnenberg, Alayne G. Quamruzzaman, Quazi Rahman, Mahmudar Mostofa, Golam Afroz, Sakila Christiani, David C. |
author_facet | Kile, Molly L. Faraj, Joycelyn M. Ronnenberg, Alayne G. Quamruzzaman, Quazi Rahman, Mahmudar Mostofa, Golam Afroz, Sakila Christiani, David C. |
author_sort | Kile, Molly L. |
collection | PubMed |
description | BACKGROUND: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the risk of arsenic-induced skin lesions appears to differ by sex. METHODS: We conducted a case-control study in 147 arsenic-exposed Bangladeshi women to assess the association between anemia and arsenic-induced skin lesions. RESULTS: We observed that the odds of arsenic-related skin lesions were approximately three times higher among women who were anemic (hemoglobin < 120 g/L) compared to women with normal hemoglobin levels [Odds Ratio (OR) = 3.32, 95 % Confidence Intervals (CI): 1.29, 8.52] after adjusting for arsenic levels in drinking water and other covariates. Furthermore, 75 % of the women with anemia had adequate iron stores (serum ferritin ≥12 μg/L), suggesting that the majority of anemia detected in this population was unrelated to iron depletion. CONCLUSIONS: Considering the magnitude of arsenic exposure and prevalence of anemia in Bangladeshi women, additional research is warranted that identifies the causes of anemia so that effective interventions can be implemented while arsenic remediation efforts continue. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-2824-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4754934 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47549342016-02-17 A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women Kile, Molly L. Faraj, Joycelyn M. Ronnenberg, Alayne G. Quamruzzaman, Quazi Rahman, Mahmudar Mostofa, Golam Afroz, Sakila Christiani, David C. BMC Public Health Research Article BACKGROUND: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the risk of arsenic-induced skin lesions appears to differ by sex. METHODS: We conducted a case-control study in 147 arsenic-exposed Bangladeshi women to assess the association between anemia and arsenic-induced skin lesions. RESULTS: We observed that the odds of arsenic-related skin lesions were approximately three times higher among women who were anemic (hemoglobin < 120 g/L) compared to women with normal hemoglobin levels [Odds Ratio (OR) = 3.32, 95 % Confidence Intervals (CI): 1.29, 8.52] after adjusting for arsenic levels in drinking water and other covariates. Furthermore, 75 % of the women with anemia had adequate iron stores (serum ferritin ≥12 μg/L), suggesting that the majority of anemia detected in this population was unrelated to iron depletion. CONCLUSIONS: Considering the magnitude of arsenic exposure and prevalence of anemia in Bangladeshi women, additional research is warranted that identifies the causes of anemia so that effective interventions can be implemented while arsenic remediation efforts continue. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12889-016-2824-4) contains supplementary material, which is available to authorized users. BioMed Central 2016-02-16 /pmc/articles/PMC4754934/ /pubmed/26880234 http://dx.doi.org/10.1186/s12889-016-2824-4 Text en © Kile et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Kile, Molly L. Faraj, Joycelyn M. Ronnenberg, Alayne G. Quamruzzaman, Quazi Rahman, Mahmudar Mostofa, Golam Afroz, Sakila Christiani, David C. A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title | A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title_full | A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title_fullStr | A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title_full_unstemmed | A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title_short | A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women |
title_sort | cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in bangladeshi women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754934/ https://www.ncbi.nlm.nih.gov/pubmed/26880234 http://dx.doi.org/10.1186/s12889-016-2824-4 |
work_keys_str_mv | AT kilemollyl acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT farajjoycelynm acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT ronnenbergalayneg acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT quamruzzamanquazi acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT rahmanmahmudar acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT mostofagolam acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT afrozsakila acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT christianidavidc acrosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT kilemollyl crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT farajjoycelynm crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT ronnenbergalayneg crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT quamruzzamanquazi crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT rahmanmahmudar crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT mostofagolam crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT afrozsakila crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen AT christianidavidc crosssectionalstudyofanemiaandirondeficiencyasriskfactorsforarsenicinducedskinlesionsinbangladeshiwomen |