Functional analysis of drug resistance‐associated mutations in the T rypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

The T rypanosoma brucei aminopurine transporter P2/TbAT1 has long been implicated in the transport of, and resistance to, the diamidine and melaminophenyl arsenical classes of drugs that form the backbone of the pharmacopoeia against African trypanosomiasis. Genetic alterations including deletions a...

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Detalles Bibliográficos
Autores principales: Munday, Jane C., Tagoe, Daniel N. A., Eze, Anthonius A., Krezdorn, Jessica A. M., Rojas López, Karla E., Alkhaldi, Abdulsalam A. M., McDonald, Fiona, Still, Jennifer, Alzahrani, Khalid J., Settimo, Luca, De Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755147/
https://www.ncbi.nlm.nih.gov/pubmed/25708978
http://dx.doi.org/10.1111/mmi.12979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755147/
https://www.ncbi.nlm.nih.gov/pubmed/25708978
http://dx.doi.org/10.1111/mmi.12979

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