West Nile Virus Infection in the Central Nervous System

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide.  Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae.  Neither antiviral drugs nor vaccines are available for...

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Detalles Bibliográficos
Autores principales: Winkelmann, Evandro R., Luo, Huanle, Wang, Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755400/
https://www.ncbi.nlm.nih.gov/pubmed/26918172
http://dx.doi.org/10.12688/f1000research.7404.1
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author Winkelmann, Evandro R.
Luo, Huanle
Wang, Tian
author_facet Winkelmann, Evandro R.
Luo, Huanle
Wang, Tian
author_sort Winkelmann, Evandro R.
collection PubMed
description West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide.  Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae.  Neither antiviral drugs nor vaccines are available for humans.  Animal models have been used to investigate WNV pathogenesis and host immune response in humans.  In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.
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spelling pubmed-47554002016-02-24 West Nile Virus Infection in the Central Nervous System Winkelmann, Evandro R. Luo, Huanle Wang, Tian F1000Res Review West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide.  Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae.  Neither antiviral drugs nor vaccines are available for humans.  Animal models have been used to investigate WNV pathogenesis and host immune response in humans.  In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system. F1000Research 2016-01-26 /pmc/articles/PMC4755400/ /pubmed/26918172 http://dx.doi.org/10.12688/f1000research.7404.1 Text en Copyright: © 2016 Winkelmann ER et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Winkelmann, Evandro R.
Luo, Huanle
Wang, Tian
West Nile Virus Infection in the Central Nervous System
title West Nile Virus Infection in the Central Nervous System
title_full West Nile Virus Infection in the Central Nervous System
title_fullStr West Nile Virus Infection in the Central Nervous System
title_full_unstemmed West Nile Virus Infection in the Central Nervous System
title_short West Nile Virus Infection in the Central Nervous System
title_sort west nile virus infection in the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755400/
https://www.ncbi.nlm.nih.gov/pubmed/26918172
http://dx.doi.org/10.12688/f1000research.7404.1
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